活性氧MCB-613,296792-62-6,4-ethyl-2,6-bis(3-pyridinylmethylene)-cyclohexanone
厂产品名字称:抗逆性氧MCB-613,296792-62-6,4-ethyl-2,6-bis(3-pyridinylmethylene)-cyclohexanone制造地:广州样式:1mg 5mg 10mg色度:99%作用:仅适用于教育科研温磬提示信息:仅采用科研课题,不允许采用人体内调查!The p160 steroid receptor coactivator (SRC) family, SRC-1/NCOA1, SRC-2/NCOA2/TIF2/GRIP1, and SRC-3/NCOA3/AIB1/RAC3/ACTR/pCIP, interact with nuclear receptors and other transcription factors to drive target gene expression and integrate growth signaling pathways on which cancer cells rely. MCB-613 is a small molecule stimulator of SRC-1, SRC-2, and SRC-3 that has been used to disrupt cancer cell homeostatic dependence on SRCs.1 MCB-613 can increase the interaction of SRCs with the coactivators CBP and CARM1 and can induce ER stress coupled to the generation of reactive oxygen species.1 Overactivation of SRCs by 1-7 µM MCB-613 was shown to selectively and dose dependently induce paraptosis in a variety of cancer cells in vitro but not in normal cells.1 At 20 mg/kg, MCB-613 was also shown to inhibit tumor growth in an MCF-7 breast cancer xenograft model in mice.1