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活性氧Artesunate-d4,1316753-15-7
发布时间:2023-03-20     作者:hao   分享到:
产品的名字大全:抗逆性氧Artesunate-d4,1316753-15-7产区:绵阳样式:1mg 5mg 10mg含量:99%作用:仅代替科研课题幸福报错:仅应用在科研开发,没能应用在机体实验操作!Artesunate-d4 is intended for use as an internal standard for the quantification of artesunate (Item No. 11817) by GC- or LC-MS. Artesunate is a derivative of artemisinin (Item No. 11816) that is active against P. falciparum in vitro (IC50 = 1.28 nM).1 It is an iron(II) oxide-reactive endoperoxide that generates reactive oxygen species (ROS) upon cleavage of its endoperoxide bridge.2 It inhibits the activity of the P. falciparum EXP1, a glutathione S-transferase (GST) that degrades hematin, with an IC50 value of 2.05 nM.3 Artesunate inhibits proliferation of germinal center B cells in vitro and prevents development of arthritis via inhibition of germinal center formation and autoantibody production in the K/BxN mouse model of rheumatoid arthritis when administered at a dose of 100 mg/kg twice per day.4 It also inhibits alveolitis and pulmonary fibrosis induced by bleomycin (Item No. 13877) in rats.5 Artesunate increases the activity of GST in mice infected with P. berghei compared to uninfected and infected control animals.6

活性氧Artesunate-d4,1316753-15-7

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