活性氧CDDO,218600-44-3
好产产品名字称:活力氧CDDO,218600-44-3产址:山东的规格:1mg 5mg 10mg饱和度:99%功用:仅代替科研课题溫馨显示:仅应用在教学科研,未能应用在身体工作!CDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM.1 By suppressing reactive oxygen and nitrogen species (ROS/RNS) formation, it promotes the cellular control of ROS/RNS levels that would lead to DNA damage associated with tumorigenesis.2 In various cancer cell lines, CDDO has been shown to specifically inhibit proliferation and induce apoptosis.2 Mechanism studies revealed that CDDO is a ligand for peroxisome proliferator-activated receptor γ, and also that it induces genes regulated by Nrf2, including heme oxygenase-1 and eotaxin-1, which play a role in antioxidant response element signaling activity.3,4,5