新产商品编码称：生物氧AEM1，1030123-90-0出产地：西安市规格尺寸：1mg 5mg 10mg色度：99%不同的用途：仅用来科技创新舒适安全提示：仅适用成果转化，不可适用人们研究！Cancer cell survival appears partly dependent on antioxidative enzymes, whose expression is regulated by the Keap1-Nrf2 pathway, to quench potentially toxic reactive oxygen species generated by their metastatic transformation.1 AEM1 is an inhibitor of gene expression induced by nuclear erythroid 2-related factor 2 (Nrf2).2 It reduces Nrf2-dependent expression of the genes encoding superoxide dismutase 1 (SOD1), heme oxygenase 1 (HO-1), thioredoxin (Trx), glutamate-cysteine ligase (GCLM), and glutathione peroxidase 2 (GPX2), as well as decreases glutathione (GSH) content in A549 cells when used at 5 µM. AEM1 enhances tert-butyl hydroperoxide-induced A549 cell death. In vivo, AEM1 (50 mg/kg) reduces tumor volume in an A549 mouse xenograft model.

想关產品：催化活性氧CDDO，218600-44-3抗逆性氧Artemisinin，63968-64-9活力性氧Artesunate-d4，1316753-15-7小编：XAQYBIO HAO，2023-5年2月20日。