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UPF-1069,1048371-03-4
发布时间:2023-03-20     作者:hao   分享到:
产品设备简称:UPF-1069,1048371-03-4产于:北京型号规格:1mg 5mg 10mg饱和度:99%的主要用途:仅在科技贴心表示:仅应用在科学研究,未能应用在人休實驗!The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. UPF-1069 is a PARP inhibitor that demonstrates a modest preference for PARP2 over PARP1 (IC50s = 0.3 and 8 µM, respectively).1 In rat models of post-ischemic brain damage, it has been shown to increase cell death in hippocampal slice cultures in a model characterized by loss of neurons through a caspase-dependent, apoptosis-like process but to be protective of cortical neurons in a model characterized by a necrosis-like process.2

UPF-1069,1048371-03-4

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