Nitrotyrosine (Peptide) Polyclonal Antibody,3-Nitrotyrosine
产品的称呼:Nitrotyrosine (Peptide) Polyclonal Antibody,3-Nitrotyrosine主产地:西安市金桥铜业跨接线的截面积大小:1mg 5mg 10mg饱和度:99%不同的用途:仅应用在科技创新幸福系统提示:仅适在教育科研,不是适在人体细胞工作!Nitrotyrosine is a post-translational modification that is formed by the nitration of tyrosine.1 Under conditions of oxidative stress, tyrosine is oxidized by reactive oxygen species (ROS) or, in the presence of hydrogen peroxide and nitrite, by myeloperoxidase (MPO) to yield a tyrosine radical that reacts with reactive nitrogen species (RNS), such as nitric oxide or peroxynitrite, to form nitrotyrosine. It exists in a free or protein-bound form and is commonly used as a marker of nitrosative or oxidative stress.2 Nitrotyrosine residues have been found in a variety of proteins, including LDL, surfactant protein A, angiotensin II, and human and bovine serum albumin.3 Free nitrotyrosine production induced by peroxynitrite is inhibited by the polyphenols epicatechin gallate, gallic acid, catechin, or epicatechin in cell-free assays, as well as in aortic rings isolated from normotensive and spontaneously hypertensive rats administered the antioxidant N-acetyl-cysteine (NAC; Item No. 20261).4,5 Nitrotyrosine levels are increased in the affected tissues of numerous pathological conditions, including atherosclerosis, cancer, ulcerative colitis, Alzheimer's disease, and Parkinson's disease.3 Autoantibodies that recognize nitrotyrosinated proteins are increased in the synovium of patients with rheumatoid arthritis and are positively correlated with joint and tendon inflammation.1 Cayman's Nitrotyrosine (Peptide) Polyclonal Antibody has been prepared by affinity purification to exclude non-nitrotyrosine antibodies generated against the antigenic peptide backbone. This antibody can be used for Western blot (WB) applications.