Aldehyde Reactive Probe (trifluoroacetate salt),627090-10-2
产品设备名号:Aldehyde Reactive Probe (trifluoroacetate salt),627090-10-2生产基地:北京样式:1mg 5mg 10mg纯净度:99%作用:仅适用于科研项目温情提醒:仅使用在科技创新,难以使用在人實驗!DNA is continually damaged by endogenous and environmental agents leading to the formation of abasic (apurinic/apyrimidinic, AP) sites that are disruptive to DNA synthesis. Aldehyde Reactive Probe (ARP) is a biotinylated reagent for the detection and quantification of AP sites in damaged DNA. ARP reacts with aldehyde groups formed when reactive oxygen species depurinate DNA, resulting in covalent linkage of biotin to these AP sites.1 The biotin-tagged DNA can then be detected using common avidin-conjugated reporters such as avidin-HRP. The ARP method is highly sensitive, enabling detection of 2.4 AP sites per 1x107 nucleotides of DNA.