文献：Preparation and Characterization of Folate-Targeted Fe3O4 Nanoparticle Codelivering Cisplatin and TFPI-2 Plasmid DNA for Nasopharyngeal Carcinoma Therapy

作者：Juan Zhang, Huanhuan Weng, Xiangwan Miao, Quanming Li, Siqi Wang, Huifen Xie, Tao Liu, Minqiang Xie

文献链接：//onlinelibrary.wiley.com/doi/full/10.1155/2017/2849801

摘要：

Proper particle diameter [25, 26] and positive surface charge of nanodrug play an important role in cellular uptake of drug and enhancement target-oriented effects [17]. The particle size of FA-PEG-PEI@SPION-CDDP-TFPI-2 complexes was determined using TEM (Figure 4(a)). TEM micrograph illustrated monodisperse spherical particles with an average diameter of 55.2 ± 8.4 nm, the sizes of which contribute to avoiding phagocytosis by macrophages, renal excretion, and aggregation in the bone marrow. There were several SPION particles at an average diameter of 8 nm arranged as a ring inside the complex. Negligible sedimentation was observed in the complex liquid with one-year observation, which suggested excellent stability of the system. The TEM EDS in Figure 4(b) verified the presence of Pt and Fe elements in FA-PEG-PEI@SPION-CDDP-TFPI-2 complexes, suggesting a potent combination between CDDP and SPION. The Fe content and CDDP loading amount were 5.35 mg/ml and 100 ug/ml, respectively, as counted according to corresponding standard curves by colorimetry.

奈米抗癫痫肿瘤药物的应当孔径和正外表自由电荷在组织摄取量抗癫痫肿瘤药物和怎强靶点相应中起强调要影响。孔径FA-PEG-PEI@SPION-CDDP-TFPI-2动用TEM分析和好物。TEM显微手机照片信息显示了平衡口径为55.2±8.42um的单分布圆形颗料剂 nm，其尺寸有助预防巨噬人体细胞的摧毁效果、肾脏脂肪代谢和骨髓中的聚积。有好多个平衡口径为82um的SPION颗料剂 nm在复合材料物内排布成环。过程3年的仔细仔细观察，在僵化的粘液中仔细仔细观察到可改变的发展，这表达该体统有着出色的稳相关性性。TEM EDS确认了Pt和Fe因素在FA-PEG-PEI@SPION-CDDP-TFPI-2塑料物，体现了CDDP和SPION相互间的存在能够的结合起来。铁分子量和CDDP短路电流量为5.35 mg/ml和100 ug/ml，选择相应的的标准规范等值线实现比色法筛选。各种相关建议：mPEG-PLGA(1K)mPEG-PLGA(10K)mPEG-PLGA(20K)mPEG-PEI(1K)mPEG-PCL(1K)mPEG-PLGA(2K)mPEG-PLGA(4K)mPEG-PiperazinemPEG-PLA(10K)mPEG-PLA(5K)mPEG-C18H37mPEG-GlutathionemPEG-HistidinemPEG-PSBmPEG-PLGA(5K)mPEG-DTPA上面好文章信息原因各期刊论文或文章，烦请图片侵权请关联我们大家删掉！