期刊论文：Receptor-Specific Delivery of Liposomes Via Folate-Peg-Chol小编：Wenjin Guo,Tina Lee,Jennifer Sudimack &Robert J. Lee参考文献跳转： 小结：A novel lipophilic conjugate of folate, folate-PEG-Chol, was synthesized and evaluated for receptor-mediated targeting of liposomes to tumor cells. Liposomes composed of DSPC/Chol/PEG-DSPE/folate-PEG-Chol (60/ 34/5/1, m/m) were taken up by cultured folate receptor-bearing KB cells via a saturable mechanism. Cellular binding of these liposomes could be competitively inhibited by free folic acid with an IC50 of 0.39 mM, indicating an extraordinarily high binding affinity. Fluorescence micrographs of KB cells treated with targeted liposomes encapsulating calcein showed that they were distributed both on the cell surface and in intracellular vesicular compartments. Targeted liposomes carrying doxorubicin were shown to be 38 times more toxic to KB cells than non-targeted control liposomes. A biodistribution study in receptor-positive tumor-bearing C57BL/6 mice showed no significant differences between the tumor uptake of folate-PEG-liposomes and non-targeted control liposomes. This study has demonstrated that cholesterol could be used as an alternative to phospholipids as an effective anchor for incorporation of a targeting ligand into liposomes.

制成了了种新型产品的备孕叶酸片亲脂性缀合物备孕叶酸片-PEG-Chol，并开展了其肾上腺素受体介导的脂质体靶点癌肿细胞系的影响。由DSPC/Chol/PEG-DSPE/孕妇孕妇备孕叶酸-PEG-Chol（60/34/5/1，m/m）组成部分的脂质体按照可趋于稳定机能被锻炼的带着孕妇孕妇备孕叶酸感觉的KB癌细胞系汲取。悬浮孕妇孕妇备孕叶酸可以寡头垄断性地能够抑制这类脂质体的癌细胞系整合，IC50为0.39 mM，反映出其整合亲和高。用包封钙黄绿素的靶向疗法疗法治疗脂质体正确处理的KB内部的荧光显微拍照屏幕上显示，这句话布置在内部表层和内部内囊泡隔室中。随带阿霉素的靶向疗法疗法治疗脂质体对KB内部的渗透性是否靶向疗法疗法治疗对应脂质体的38倍。在蛋白激酶阳性反应良性淋巴肿瘤攜帶C57BL/6小鼠中的微生物分布不均探究反映出，DHA-PEG脂质体和非靶点药物较脂质体的良性淋巴肿瘤摄食中没不错区别。这种探究反映出，碳水化合物可能有所作磷脂的代用品，有所作将靶点药物配体参入脂质体的更有效锚。相应推荐英文：DPPE-PEG-BIOTINDPPE-PEG-COOHDPPE-PEG-MalDPPE-PEG-N3DPPE-PEG-NH2DPPE-PEG-SCDSPE(Sodium salt)-PEG-COOHDSPE(Sodium salt)-PEG-NH2DSPE(Sodium salt)-PEG-OHDLPE-PEG-COOHDLPE-PEG-MalDLPE-PEG-NH2DLPE-PEG-SC综上所述稿件介绍渠道四种刊物或文章，请谅解侵权案请找话题大家误删！