论文参考文献：Targeted delivery and triggered release of liposomal doxorubicin enhances cytotoxicity against human B lymphoma cells笔者：T Ishida a 1, M.J Kirchmeier a 2, E.H Moase a, S Zalipsky b, T.M Allen 论文参考文献链接转换： 提要：radiolabeled [125I]TI were prepared and injected into the tail vein of mice at a PL dose of 0.5 μmol/mouse. Circulation times increased with increasing concentration of mPEG-DSPE in either DOPE or DOPE/CHEMS liposome formulations (Fig. 6A,B). Approximately 5–10% of the injected liposomes still remained in the blood 24 h after injection of liposomes containing 10 mol% mPEG-DSPE. Injection of DOPE or DOPE/CHEMS liposomes that were not stabilized with mPEG-DSPE resulted in rapid clearance of the liposomes. Liposomes accumulated primarily in the liver and spleen (not shown). Inclusion of from 2 to 9 mol% of mPEG-S-S-DSPE did not increase the circulation times for either the DOPE (Fig. 6C) or DOPE/CHEMS (Fig. 6D) formulations. All mPEG-S-S-DSPE formulations contained 1 mol% mPEG-DSPE to mimic the effect of adding 1 mol% coupling lipid to the formulations in targeting experiments. Increasing amounts of mPEG-S-S-DSPE in the formulations did not increase circulation half-lives of the formulations to any significant extent (Fig. 6A,B), likely because the mPEG-S-S-DSPE was rapidly cleaved in plasma.

为了能让断定脂质制度剂的药代和力学结构，提纯了包含有放射学性标记图片的[125I]TI的脂质体，后以0.5μmol/小鼠的PL含水量滴注到小鼠的尾冠状动脉中。重复用时跟随着DOPE或DOPE/CHEMS脂质制度剂中mPEG-DSPE酸度的不断多而不断多。打针液体具有10mol%mPEG-DSPE的脂质体24小时内后，约5-10%的打针液体脂质体仍留下血液循环系统中。打针液体未经许可mPEG-DSPE稳固的DOPE或DOPE/CHEMS脂质体可如何快速去除脂质体。脂质体最主要的凝聚在肝胀和脾脏中。参加2至9mol%的mPEG-S-S-DSPE也不会提高DOPE或DOPE/CHEMS药品的无限再循环时。各种mPEG-S-S-DSPE药品均有1 mol%mPEG-DSPE，以模拟机在靶向疗法实验设计中向药品中添加图片1 mol%偶联脂质的成效。药品中mPEG-S-S-DSPE含磷量的提高并不会同质性变长药品的无限再循环半衰期，这或者是由于mPEG-S-S-D SPE在血浆中讯速裂解。有关系网友推荐：RB-PEG-DSPESTA-PEG-CHOSTA-PEG-COOHSTA-PEG-FASTA-PEG-FITCSTA-PEG-MalSTA-PEG-NBDSTA-PEG-NH2STA-PEG-OHSTA-PEG-SCSTA-PEG-SH超过句子內容来源于各项期刊杂志或论文参考文献，见谅版权侵权请连接他们删去！