论文资料：磷脂呈现的PEI基nm媒体在机体siRNA*多药耐药性*链接搜索：//www.nature.com/articles/gt201497做者：埃塞克斯郡中北部G纳瓦罗P·萨巴钱达尼，条理膜M Trivedi，S Movassaghian＆总监裁托尔奇林节选：物理瘤中P-糖蛋清过表答介导的多药抗药力(MDR)是不同肿瘤放疗化疗挫败的首要缘由。本探究分析评估了磷脂表达的分太低子量聚乙稀亚胺(DOPE-PEI)纳米技术技术级媒体使用于动脉运输*P-糖蛋清siRNA至*的结果，决定性对象是改进乳腺纤维纤维癌的MDR。第一方面，我探究了DOPE-PEI纳米技术技术级媒体的海洋生物匀称甚至PEG镀层在皮下组织乳腺纤维纤维*建模方法中的使用。注塑后四几小时，PEG化媒体使用改进的渗透到性和滞留旅客定律，在物理瘤中1个了了8%的注塑用量(ID)，会因为PEG介导的无限循环时候变长，在血清中1个了了22%的ID。然后，我确认了DOPE-PEI/siRNA介导的P-gp调整聯合阿霉素(Dox)肿瘤放疗化疗在MCF-7/MDR异种囊胚移植瘤中的治较果果和安全等级高性。每天注塑siRNA纳米技术技术级中药药物制剂和Dox，不断地短短5周，使*对最初错误用量的Dox制造比较比较敏感状态，并使*体积太与对应组对比改小了几倍。这一种对Dox治较果果的改进归因于DOPE-PEI中药药物制剂介导的切去*中为显著的字段炎症因子聊天P-gp调整。

Multidrug resistance (MDR) mediated by P-glycoprotein overexpression in solid tumors is a major factor in the failure of many forms of chemotherapy. Here we evaluated phospholipid-modified, low-molecular-weight polyethylenimine (DOPE-PEI) nanocarriers for intravenous delivery of anti-P-pg siRNA to tumors with the final goal of modulating MDR in breast cancer. First, we studied the biodistribution of DOPE-PEI nanocarriers and the effect of PEG coating in a subcutaneous breast tumor model. Four hours postinjection, PEGylated carriers showed an 8% injected dose (ID) accumulation in solid tumor via the enhanced permeability and retention effect and 22% ID in serum due to a prolonged, PEG-mediated circulation. Second, we established the therapeutic efficacy and safety of DOPE-PEI/siRNA-mediated P-gp downregulation in combination with doxorubicin (Dox) chemotherapy in MCF-7/MDR xenografts. Weekly injection of siRNA nanopreparations and Dox for up to 5 weeks sensitized the tumors to otherwise non-effective doses of Dox and decreased the tumor volume by threefold vs controls. This therapeutic improvement in response to Dox was attributed to the significant, sequence-specific P-gp downregulation in excised tumors mediated by the DOPE-PEI formulations.广州pg电子娱乐游戏app 菌物给出有关系品牌：DSPE-PyreneDSPE-ThiolDSPE-PEG-GE11(二硬脂酰基磷脂酰工业乙醇胺-聚乙二醇-*生殖细胞表面生长期指数EGFR靶点肽)DSPE-PEG-HisDSPE-PEG-cRGD(二硬脂酰基磷脂酰甲醇胺-聚乙二醇-资源共享素靶点环肽)ALC-0315DOPE-PEG-MalDSPE-PEG-M2pepDSPE-PEG-cisplatinDSPEGPC3靶向疗法肽-PEG-DSPE综上所述软文项目起源以及中文核心期刊或期刊论文，如果侵权案请连系咱们卸载！