期刊论文：MPEG-DSPE polymeric micelle for translymphatic chemotherapy of lymph node metastasis小说作品：Xue Li a 1, Qing Dong a 1, Zhiqiang Yan b, Weiyue Lu a, Lingling Feng c, Cao Xie a, Zuoxu Xie a, Bingxia Su a, Min Liu 论文外链：

The MPEG-DSPE/DOX micelle prepared were of spherical morphology with a particle size of 20 ± 5 nm. The uptake rates of DOX and MPEG-DSPE/DOX micelle by A375 cells were 51.2% and 88.7%, respectively. The phagocytosis rate of MPEG-DSPE/Rhodamine B micelle by RAW264.7 cells was 17.2-fold lower than for Rhodamine B alone. After subcutaneous injection, MPEG-DSPE micelle underwent lymphatic absorption and accumulated in popliteal lymph nodes. MPEG-DSPE/DOX micelle significantly alleviated damage to the subcutaneous tissue of the injection sites compared with DOX alone. We established a model of nude mice bearing lymph node metastasis of A375 cells. After subcutaneous injection, the weights of both the popliteal and iliac lymph nodes of the MPEG-DSPE/DOX micelle group were significantly lower than in the saline and DOX groups. MPEG-DSPE/DOX micelle effectively killed the tumor cells in popliteal and iliac lymph nodes. 

备制的MPEG-DSPE/DOX胶束呈球体，粒级为20±5nm。A375细胞核核对DOX和MPEG-DSPE/DOX胶束的摄食率分別为51.2%和88.7%。RAW264.7细胞核核对MPEG-DSPE/罗丹明B胶束的腐化率比一个人用罗丹明B低17.2倍。肉里打针后，MPEG-DSPE胶束会出现腮腺吸引并聚集在腘腮腺结中。与分开安全使用DOX相对，MPEG-DSPE/DOX胶束相关系数改善了滴注脏器皮下组织组织化组织化的直接损伤。我们的创立了挟带A375生殖细胞淋疤结转出的裸鼠模式化。皮下组织组织化滴注后，MPEG-DSPE/DOX胶束组的腘和髂淋疤结毛重均相关系数底于生理方面建议使用淡盐水配合组和DOX组。重要性比较适合：DSPE-PEG-SHDSPE-PEG-SilaneDSPE-PEG-SP2-AADSPE-PEG-SSDSPE-PEG-TCODSPE-PEG-TetrazineDSPE-PEG-TMSDSPE-PEG-TPPDSPE-PEG-Transferrin DSPE-PEG-VE, MW:2000DSPE-PEG-β-cyclodextrinDSPE-PEG-Ald