文章：Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy专著图片链接：//www.tandfonline.com/doi/full/10.2147/IJN.S152312#d1e205诗人：Jiajiang Xie,Zhongxiong Fan,Yang Li,Yinying Zhang,Fei Yu,Guanghao Su提要：Preparation and characterization of pH-sensitive DSPE-PEG-Imide-MTX assembling micellar nanoparticles loaded with CUR (MTX-Imine-M-CUR)Because of inherent amphiphilicity, DSPE-PEG-Imine-MTX and DSPE-MPEG could spontaneously self-assemble into micellar nanoparticles (MTX-Imine-M) composed of an inner hydrophobic DSPE core and an outside hydrophilic PEG shell with a self-targeting prodrug corona when exposed to the aqueous solution. The CUR drug could be encapsulated within the hydrophobic core of MTX-Imine-M (MTX-Imine-M-CUR) through hydrophobic interactions. The MTX-Imine-M-CUR nanoparticles were characterized by dynamic light scattering (DLS) and transmission electron microscope (TEM). In addition, the M-CUR (nanocarriers were self-assembled by DSPE-MPEG) and the MTX-Amide-M-CUR (nanocarriers were self-assembled by DSPE-PEG-Amide-MTX and DSPE-MPEG) were fabricated as comparative formulations (Figure 1B). The TEM observation of all drug formulations (Figure 2A–C) confirmed the monodispersed spherical nanoparticles. With DLS measurement, all nanoparticles showed a mean hydrodynamic particle size of 20–30 nm with negative surface charge (Figure 2A–C), which might facilitate preventing potential aggregations via electrostatic repulsion and decrease the nonspecific interaction between nanoparticles and plasma protein/red blood cells. 

是因为其僵板的两亲性，当外露于水悬浊液中时，DSPE-PEG-Imine-MTX和DSPE-MPEG还可以参与地自按装成胶束納米塑料再生颗粒（MTX-Imine-M），该納米塑料再生颗粒由内部管理疏水DSPE重要和外部结构亲水PEG的外壳组合而成，具备着自靶向疗法前药冠。CUR中药可不可以顺利借助疏水彼此之间效果包封在MTX-Imine-M（MTX-Imine-M-CUR）的疏水核心理念内。顺利借助动态的光散射（DLS）和微电子散射微电子体视显微镜（TEM）对MTX-Imine-M-CURnm再生颗粒对其进行了定性分析。

此外，M-CUR（纳米载体由DSPE-MPEG自组装）和MTX-酰胺-MCUR（纳米粒子由DSPE-PEG-酰胺-MTX和DSPE-MPEG自行组装）被制备为比较制剂。所有药物制剂的TEM观察证实了单分散的球形纳米颗粒。通过DLS测量，所有纳米粒子的平均流体动力学粒径为20-30nm，表面带负电荷，这可能有助于通过静电排斥防止潜在的聚集，并减少纳米粒子与血浆蛋白/红细胞之间的非特异性相互作用。

相应的分享物品：DSPE-PEG-SCDSPE-PEG-SCMDSPE-PEG-SGDSPE-PEG-SHDSPE-PEG-SilaneDSPE-PEG-SP2-AADSPE-PEG-SSDSPE-PEG-TCODSPE-PEG-TetrazineDSPE-PEG-TMS之内好的文章信息从何而来常见中文核心期刊或学术论文，如不侵犯肖像权请保持联系他们册除！