多肽渗透型含糖共聚物电纺玻璃纤维

Abstract

Oligo(Glu70-co-Leu30), a peptide synthesized by protease catalysis, is functionalized at the N-terminus with a 4-pentenoyl unit and grafted to polyLSL[6′Ac,6″Ac], a glycopolymer prepared by ring-opening metathesis polymerization of lactonic sophorolipid diacetate. First, polyLSL[6'Ac,6”Ac] fiber mats are fabricated by electrospinning. Oxidation of the fiber mats and subsequent reaction with cysteamine lead to thiol-functionalized fiber mats with no significant morphology changes. Grafting of the alkene-modified oligopeptide to thiol-functionalized polyLSL[6′Ac,6″Ac] fiber mats is achieved via “thiol-ene” click reaction. X-ray photoelectron spectroscopy analysis to characterize peptide grafting reveals that about 50 mol% of polyLSL[6′Ac,6′′Ac] repeat units at fiber surfaces are decorated with a peptide moiety, out of which about 1/3 of the oligo(Glu70-co-Leu30) units are physically adsorbed to polyLSL[6′Ac,6′′Ac]. The results of this work pave the way to precise engineering of polyLSL fiber mats that can be decorated with a potentially wide range of molecules that tailor surface chemistry and biological properties.

    推荐了聚LSL[6’Ac,6” Ac]电纺食物纤维的织造和nvme固态定量分析时候，并记述了聚LSL[6’Ac,6” Ac]非织造毡与多肽的各种各样耦联操作过程。X光电子束光谱仪进行分析最终结果表示，约表面能50mol%的聚LSL[6’Ac,6” Ac]从复模快被多肽装饰，中仅有1/3的多肽被聚LSL[6’Ac,6” Ac]数学吸附性。