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活性氧Isosilybin,72581-71-6
发布时间:2023-03-20     作者:hao   分享到:
物产品标题称:催化活性氧Isosilybin,72581-71-6生产地:北京要求:1mg 5mg 10mg含量:99%借款用途:仅使用于科研工作和谐表明:仅使于研发,不可能使于人体人体工作!Isosilybin is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities.1,2,3 It inhibits lipid peroxidation in rat liver microsomes (IC50 = 32 μM) and reduces ADP/Fe3+-induced malondialdehyde (MDA) production and lactate dehydrogenase (LDH) release in rat hepatocytes.1 Isosilybin inhibits the production of reactive oxygen species (ROS), MDA and LDH release, and reduction in total antioxidant capacity induced by amyloid-β (25-35) (Aβ25-35) in HT-22 hippocampal cells.2 It also increases protein and mRNA expression of heme oxygenase-1 (HO-1), glutathione S-transferase (GST), and the aldo-keto reductases (AKCR) 1C1 and AKCR1C2 in HT-22 cells. In vivo, isosilybin (50 and 100 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a DU145 prostate cancer mouse xenograft model.3 It also reduces expression of the tumor angiogenesis markers CD31, nestin, VEGF, VEGFR1, VEGFR2, phospho-Akt, and HIF-1α in tumor tissue without reducing blood vessel count in non-cancerous liver, lung, and kidney tissue in DU145 tumor-bearing mice.

活性氧Isosilybin,72581-71-6

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