OBA-09,856095-68-6,2-(1,2-dioxopropoxy)-benzoic acid
商商品编码称:OBA-09,856095-68-6,2-(1,2-dioxopropoxy)-benzoic acid主产地:山东型号规格:1mg 5mg 10mg色度:99%的主要用途是什么:仅代替成果转化浪漫提示卡:仅应用在科学,不会应用在人體试验!OBA-09 is an ester of pyruvate and salicylic acid that has neuroprotective properties.1 It decreases lactate dehydrogenase (LDH) release and prevents cell death induced by NMDA or zinc, and reduces the production of reactive oxygen species (ROS) induced by oxygen-glucose deprivation in mixed rat primary cortical cells when used at concentrations of 10 and 15 mM. OBA-09 (10 mg/kg) reduces infarct volume by 89.9% and decreases expression of IL-1β, inducible nitric oxide synthase (iNOS), COX-2, and TNF-α in the brain in a rat model of ischemia induced by middle cerebral artery occlusion (MCAO).1,2 It improves motor performance in the rotarod test in the same model when administered at a dose of 10 mg/kg.1