产品的命名：6-OHDA (hydrobromide)，636-00-0出产地：武汉样式：1mg 5mg 10mg溶解度：99%领域：仅适用于研究祥和系统提示：仅广泛在科研开发，不许广泛在人的身体实践！6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson's disease in rodents.1 It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively.2 Intracisternal administration of 6-OHDA (200 μg) decreases dopamine (Item No. 21992) and norepinephrine (Item No. 16673) levels in rat brain.3 It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM.4,5 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.5,6

关联物料：Disulfiram-d20，1216403-88-1Quercetin-7-O-β-D-Glucopyranoside，491-50-9Artesunate，88495-63-0，butanedioic acid导出：XAQYBIO HAO，202五年9月18日。