车辆英文名称：3-AP，143621-35-6原产地：北京的规格：1mg 5mg 10mg溶解度：99%的主要用途是什么：仅采用科学研究幸福报错：仅应适用于教学科研，没能应适用于人体细胞实践！Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.1 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity.2 At 5 μM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair.2 It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species.3 Furthermore, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis.4

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