ICG maleimide马来酰亚胺,ICG-MAL,吲哚菁绿

英文字母名：ICG maleimide，ICG-MAL
中文版名：吲哚菁绿-马来酰亚胺
铜网外观：绿色的粉未
降解度：二氯丁烷
饱和度：95%+
空间化学式：

ICG maleimide马来酰亚胺,ICG-MAL,吲哚菁绿

ICG is a tricarbocyanine-type dye with NIR-absorbing properties (peak absorption around 800 nm) and emission maximum at 807 nm (10% v/vDMSO/PBS). Little absorption in the visible range accounts for the low autofluorescence, tissue absorbance, and scattering at NIR wavelengths (700-900 nm).

The maleimide of the ICG dye offers the opportunity to develop optimal conjugates. Maleimide active group provides an efficient and convenient way to selectively link ICG dye to sulfhydryl groups (free thiol, R-SH) on various substrates (antibodies[1], peptides, proteins, oligonucleotides, small molecule drugs etc.) at neutral (physiological) pH without any activation. Maleimides have very low reactivity with amines, alcohols, and phenols (incl. tyrosine and histidine) and do not react with histidine and methionine thus providing very high labeling selectivity.

It has been reported that conjugation to some antibodies may cause decrease in fluorescence intensity of ICG bound to antibody due to the formation of H-dimers4. However, fluorescence is restored after cell binding and internalization, which can be used to design an activatable NIR fluorescent probe. Fluorescence intensity of the unbound ICG-antibody conjugate can be dramatically increased (up to 50-fold) by addition of SDS and β-mercaptoethanol, which diminishes π- π stacking5.

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ICG-PEG4-Thiol

ICG-PEG4-NHS

ICG-PEG5-NH2

ICG-PEG4-MAL

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ICG-FA-PPD  吲哚菁绿-叶酸片掩盖PEI-PEG-钆酸

RGD-PLS-ICG  吲哚菁绿-RGD遮盖聚乙二醇化脂质体

C18-PEG-ICG

ICG-PEG-Silane 吲哚菁绿-聚乙二醇-硅烷

ICG-PEG-Lipoic acid,  ICG-PEG-LA吲哚菁绿-聚乙二醇-硫辛酸史

ICG-PEG-Epoxides (EPOX) 吲哚菁绿-聚乙二醇-环氧漆化物

ICG-PEG-Valeric Acids (VA) 吲哚菁绿-聚乙二醇-缬草酸

ICG-PEG-Chloride 吲哚菁绿淡化聚乙二醇氯化物

ICG-PEG-TZ/Tetrazine  吲哚菁绿突显聚乙二醇四嗪

ICG-PEG-CHEMS 吲哚菁绿遮盖聚乙二醇半虎珀酸热量

ICG-PEG-DBCO  吲哚菁绿绘制聚乙二醇环辛炔

CG-PEG-ICG  吲哚菁绿-聚乙二醇-壳聚糖

ICG-PEG-Chitosan   吲哚菁绿-聚乙二醇-壳聚糖

ICG-PEG-Dextran   吲哚菁绿掩盖聚乙二醇葡聚糖/右旋糖酐

ICG-PEG-Galactose  吲哚菁绿掩盖聚乙二醇半乳糖

ICG-PEG-Mannose   珠露糖

ICG-PL-PEG-mAb 梳理素α(v)β₃单克隆抵抗能力

APT-PEG-ICG-Der-02   MUC1适体的靶配体APT-聚乙二醇-吲哚菁绿

ICG-PEG-MTX  甲氨蝶呤

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GNR-PEG-ICG  奈米金棒-聚乙二醇-吲哚菁绿

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双特点ICG研究物ICG-PEG8-Sulfo-OSu

双性能ICG随之出现物ICG-PEG4-Sulfo-OSu

ICG随之出现物ICG-Sulfo-OSu

ICG-PL-PEG 磷脂化的聚乙二醇

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ICG-PEG-Lipoic acid, ICG-PEG-LA吲哚菁绿-聚乙二醇-硫艰辛

ICG-PEG-TZ/Tetrazine 吲哚菁绿遮盖聚乙二醇四嗪

ICG-PEG-DBCO 吲哚菁绿修饰语聚乙二醇环辛炔

CG-PEG-ICG 吲哚菁绿-聚乙二醇-壳聚糖