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mPEG-PCL-PLL纳米胶束的合成与基因负载性能研究
发布时间:2025-07-24     作者:kx   分享到:
论文:可生物工程化学降解阳亚铁离子三嵌段共聚物mPEG-PCL-PLL的结合还有其主要用于siRNA递送友链://www.sciencedirect.com/science/article/abs/pii/S016836591100681X小编:若谷 奇 1 2,颜值 湖 6号,资阳 燕 1 2,陈学思 1,黄玉斌 1,夏 滨井 1节选:是可以通过对mPEG-PCL端部羟基确定叠氮化,再对叠氮基确定氢化,分解了端氨基甲氧基聚乙二醇-b-聚己内酯(mPEG-PCL-NH 2 )。以此来加剧ε-CBz(L-赖氨酸)-N-羧酸酐的开环整合,能够阳铝铝正离子三嵌段共聚物甲氧基聚乙二醇-b-聚己内酯-b-聚L-赖氨酸(mPEG-PCL-PLL)。该共聚物可在底层的水中简单自拆装成具备着疏水主要和阳铝铝正离子冠层的纳米技术级胶束。于是,什么和什么是可以进两步与阴铝铝正离子siRNA黏结,现已应用在染色体递送。

mPEG-PCL-PLL

Amino-terminated methoxy poly(ethylene glycol)-b-poly(ε-caprolactone) (mPEG-PCL-NH2) was synthesized by azidizing the end OH group of mPEG-PCL and by subsequent hydrogenation of the azido group. It was used to initiate ring-opening polymerization of ε-CBz (L-lysine)-N-carboxyanhydride to obtain cationic triblock copolymer methoxy poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(L-lysine) (mPEG-PCL-PLL). The copolymer could self-assemble directly in water into nanoscale micelles with a hydrophobic core and a cationic corona. Therefore, they can further complex with anionic siRNA for possible application in gene delivery.宝鸡pg电子娱乐游戏app 生物制品出示对应的产品:PLL-OPSSTrt-PLLFITC-PLLPGA-AldehydePGA-N3PGA-SHPGA-BiotinPGA-NH2PGA-ALKPGA-OPSSTrt-PGA这些新闻稿件主要内容特征各样刊物或资料,见谅侵犯商标权请链接小编删除文件!