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mPEG-PCL-PLL纳米胶束的合成与基因负载性能研究
发布时间:2025-07-24     作者:kx   分享到:
期刊论文:可生物技术降解塑料阳阴离子三嵌段共聚物mPEG-PCL-PLL的分解及用到siRNA递送微信链接://www.sciencedirect.com/science/article/abs/pii/S016836591100681X小说作家:若谷 奇 1 2,变美 湖 5号,乐山市 燕 1 2,陈学思 1,黄玉斌 1,夏 滨井 1节选:经由对mPEG-PCL未端羟基参与叠氮化,再对叠氮基参与氢化,合出了端氨基甲氧基聚乙二醇-b-聚己内酯(mPEG-PCL-NH 2 )。谨以影起ε-CBz(L-赖氨酸)-N-羧酸酐的开环缩聚,赢得阳化合物三嵌段共聚物甲氧基聚乙二醇-b-聚己内酯-b-聚L-赖氨酸(mPEG-PCL-PLL)。该共聚物可在水内立即自按装成有疏水关键和阳化合物冠层的nm级胶束。往往,它是可以拓宽渠道一个脚印与阴化合物siRNA组合,即将采用人类基因递送。

mPEG-PCL-PLL

Amino-terminated methoxy poly(ethylene glycol)-b-poly(ε-caprolactone) (mPEG-PCL-NH2) was synthesized by azidizing the end OH group of mPEG-PCL and by subsequent hydrogenation of the azido group. It was used to initiate ring-opening polymerization of ε-CBz (L-lysine)-N-carboxyanhydride to obtain cationic triblock copolymer methoxy poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(L-lysine) (mPEG-PCL-PLL). The copolymer could self-assemble directly in water into nanoscale micelles with a hydrophobic core and a cationic corona. Therefore, they can further complex with anionic siRNA for possible application in gene delivery.西安市pg电子娱乐游戏app 生态学供应相关联商品:PLL-OPSSTrt-PLLFITC-PLLPGA-AldehydePGA-N3PGA-SHPGA-BiotinPGA-NH2PGA-ALKPGA-OPSSTrt-PGA不低于文章标题主要内容渠道特殊杂志期刊或学术论文,若有侵权商标请建立联系咱们删出!