论文参考文献：Preparation and Characterization of Folate-Targeted Fe3O4 Nanoparticle Codelivering Cisplatin and TFPI-2 Plasmid DNA for Nasopharyngeal Carcinoma Therapy诗人：Juan Zhang, Huanhuan Weng, Xiangwan Miao, Quanming Li, Siqi Wang, Huifen Xie, Tao Liu, Minqiang Xie论文参考文献连接：//onlinelibrary.wiley.com/doi/full/10.1155/2017/2849801前言：considered the cross-coupling reaction between the above cationic carriers and nonionic water-soluble polymers PEG to increase the solubility and decrease aggregation of the composites. Besides that, the combination between CDDP and aldehyde sodium alginate modified SPION is more capable of adsorbing PEG modified PEI via electrostatic interaction due to the improved biocompatibility, water-solubility, and longer circulation time in blood. Meanwhile, the targeting FA-PEG-PEI was prepared by amidation reaction between the carboxyl groups of FA and amino groups of NH2-PEG-OH. Finally, FA-PEG-PEI@SPION-CDDP-TFPI-2 nanocomplex was performed by linking FA-PEG-PEI with SPION-CDDP and CDDP according to appropriate proportion. In vitro assay demonstrated the superiority of the nanocomplex in specific targetability for FR+ tumors.

了解了所诉阳铝阴阳离子承载或非铝阴阳离子水溶解出来性配位聚苯胺PEG之間的交错偶联发应，以提供符合装修材料的溶解出来度并才能减少聚合。还有，可能动物相无水磷酸氢、水溶解出来性和血液反复的系统反复的期限更长，CDDP和醛-海藻颗粒酸钠绘制的SPION之間的乐队组合更能进行静电放电彼此之间功能溶解PEG绘制的PEI。同一，凭借FA的羧基与NH2-PEG-OH的氨基相互间的酰胺化体现光催化原理了靶向药物FA-PEG-PEI。在最后，FA-PEG-PEI@SPION-CDDP-TFPI-2凭借将FA-PEG-PEI与SPION-CDDP和CDDP按十分百分比衔接，实施纳米级结合物的光催化原理。离体检验意味着，微米挽回物在FR+恶性肿瘤的特男人靶点性等方面包括优胜性。相关联推见：Trt-PEG-OHBn2-PEG-OHBr-CH2CO-NH-PEG-OHOH-PEG-RGDOH-PEG-CH2COOtBuS-Acetyl-PEG-OHDA-PEG-OHBr-PEG-OHDBCO-PEG-OHHZ-PEG-OHPhthalimide-PEG-OH上述好的文章方式来源地各大论文期刊或资料，知悉侵权商标请保持联系各位删除文件！