资料：Preparation and Characterization of Folate-Targeted Fe3O4 Nanoparticle Codelivering Cisplatin and TFPI-2 Plasmid DNA for Nasopharyngeal Carcinoma Therapy小说作品：Juan Zhang, Huanhuan Weng, Xiangwan Miao, Quanming Li, Siqi Wang, Huifen Xie, Tao Liu, Minqiang Xie文献综述外部链接：//onlinelibrary.wiley.com/doi/full/10.1155/2017/2849801英文论文：Our previous study has revealed that TFPI-2 is expressed at a low level in NPC cells and tissues [16]. As proof of concept we use FA as targeting molecules, which conjugated to amino-terminated polyethylene glycol (NH2-PEG-COOH) and polyethylenimine (PEI) to perform cationic polymers (FA-PEG-PEI) via amidation. Aldehyde sodium alginate modified Fe3O4 magnetic particles coated cisplatin (SPION-CDDP) was constructed with the above cationic polymer to obtain composite carriers (FA-PEG-PEI@SPION-CDDP), which then adsorbed TFPI-2 pDNA via electrostatic interaction to obtain the FA-targeted, CDDP, and TFPI-2-coated nanocomposites (FA-PEG-PEI@SPION-CDDP-TFPI-2). In vitro assays indicated that the novel compounds possessed excellent load-carrying capacity and drug stability and showed negligible cytotoxicity and enhanced targetability to FR positive (FR+) NPC HNE-1 cells.

研发揭示，TFPI-2在鼻咽癌结构细胞和结构中的表达出质量较低。为理念检验，他们利用FA为靶向疗法团伙，它与氨基封相对定位聚乙二醇（NH2-PEG-COOH）和聚丁二烯亚胺（PEI）共轭，经过酰胺化养成阳正离子汇聚物（FA-PEG-PEI）。用以上阳阴阴阳离子配位高分子勾勒了醛-海草酸钠改良的Fe3O4带磁离子覆盖顺铂（SPION-CDDP），以换取符合承重(FA-PEG-PEI@SPION-CDDP)，那么确认靜電主动做用过滤TFPI-2 pDNA，换取FA靶向药物疗法、CDDP和TFPI-2涂覆的纳米级符合食材(FA-PEG-PEI@SPION-CDDP-TFPI-2).休外应力测试意味着，新无机化合物具优质的承重本事和性药物平衡性，对FR弱阳（FR+）NPC HNE-1受损细胞膜的受损细胞膜毒副作用能够改变不记，靶向药物疗法性加强。对应推介：OH-PEG-CH2COOtBuS-Acetyl-PEG-OHDA-PEG-OHBr-PEG-OHDBCO-PEG-OHHZ-PEG-OHPhthalimide-PEG-OHPLL-PEG-OHPLGA(10K)-PEG-OHSilane-PEG-OH以下句子文章主要来源以及中文核心期刊或医学文献，如果侵权案请去联系企业册除！