论文资料：游动先决条件下可生物学分解微球与组织上皮细胞上皮细胞激活卡内皮组织上皮细胞的特男人附着链接转换：//etd.ohiolink.edu/acprod/odb_etd/etd/r/1501/10?clear=10&p10_accession_num=ohiou1040071303我们：达拉尔，米林德·K节选：宽泛的在不同各样病症大环境中，不同内皮癌上皮细胞系上皮细胞系迁移原子核式 (ECAM) 的传达也许会增高，这令这样原子核式作为方向药剂递送方案设计的有吸引顾客力的靶点。一个技术是安全使用暗含 mAb 的缩聚物可海洋动物体光降解塑料微球来靶点口服药传达增高的 ECAM。小编运用海洋动物体素-亲和素催化技术将 mAb 与 E-选素或 ICAM-1 偶联到由海洋动物体素化的聚乳酸-聚乙二醇 (PLA-PEG-海洋动物体素) 共聚物制造而成的微球上。小编测式了得到的 mAb 包被的可海洋动物体光降解塑料颗料人与人之间脐冠状动脉内皮癌上皮细胞系 (HUVEC) 的上皮细胞系迁移性。小编看到，mAb 包被的 PLA-PEG-海洋动物体素微球对 4 小的时候后 E-选素和 ICAM-1 传达技术较高的 IL-1β 促活开通卡的 HUVEC 的上皮细胞系迁移性好于对不传达 E-选素且 ICAM-1 传达技术较低的未促活开通卡 HUVEC 的上皮细胞系迁移性。小编还看到上皮细胞系迁移力依懒于截取能力。于此，小编看到*E-选素包被微球对4小的时候IL-1β促活开通卡的HUVEC的选性与主要用于绘制*E-选素包被微球的*E-选素溶液浓度广泛有关于。这样后果证明，包被有*ECAM单克隆*体的PLA-PEG-海洋动物体素颗料可主要用于选性地将药剂靶点口服药发炎布位的内皮癌上皮细胞系。

AbstractIn a variety of disease settings the expression of various endothelial cell adhesion molecules (ECAMs) appears to be increased, making these molecules attractive targets for directed drug delivery schemes. One approach is to use polymeric biodegradable microspheres bearing a mAb for an ECAM whose expression is increased. We used biotin-avidin chemistry to couple a mAb to E-selectin or ICAM-1 to microspheres made from a biotinylated poly (lactic acid) poly (ethylene glycol) (PLA-PEG-biotin) copolymer. We tested the adhesion of the resulting mAb coated biodegradable particles to human umbilical vein endothelial cells (HUVEC). We found that the mAb coated PLA-PEG-biotin microspheres show high specific adhesion to 4 hr. IL-1β activated HUVEC expressing high levels of E-selectin and ICAM-1 relative to the level of adhesion to unactivated HUVEC that express no E-selectin and a low level of ICAM-1. We also found that the adhesion was shear stress dependent. Additionally, we have found that the selectivity of anti-E-selectin coated microspheres to 4 hr. IL-1β activated HUVEC is a strong function of the concentration of anti-E-selectin used to generate the anti-E-selectin coated microspheres. These results suggest that PLA-PEG-biotin particles coated with mAbs to ECAMs could be used to selectively target drugs to endothelium present at sites of inflammation.北京pg电子娱乐游戏app 菌物展示 涉及到品牌：mPEG-PLAPLA-PEG-SCFA-PEG-PLAMal-NH-PEG-PLAMal-PEG-PLAGalactose-PEG-PLA上文章标题信息内容的来源种类杂志期刊或论文资料，烦请侵犯知识产权请建立联系你们删除文件！