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PCL-PEG-Mal共聚物的合成与功能化
发布时间:2025-07-22     作者:kx   分享到:
论文参考文献:马来酰亚胺官能化聚(ε-己内酯)-嵌段-聚乙二醇(PCL-PEG-MAL):分解成、纳米级粉末行成和硫醇共轭连接://onlinelibrary.wiley.com/doi/abs/10.1002/macp.200900025小编:吉胜祥, 朱正熙, 托马斯·R·霍伊, 克里斯托弗·W·马科斯科节选:自动合成了含带窄多减少性的羧酸封下聚(ε-己内酯)(PCL-COOH),并将其与聚(乙二醇)(HO-PEG-OH)偶联,得出PCL-PEG-OH共聚物。随后将PCL-PEG-OH中的羟基转化率为马来酰亚胺基团,得出含带70–90%马来酰亚胺官能团的马来酰亚胺封下PCL-PEG-MAL。在的碰撞混合式化学合成了漆层含带马来酰亚胺官能团的微米级小粒。在动态图片光散射分析粒级和粒级分布不均。还证实了备份谷胱甘肽与沙盘模型马来酰亚胺和几种MAL官能团微米级小粒的配合。的使用Ellman免疫试剂测定了小粒漆层可及马来酰亚胺的量,的范围为≈51–67%。

PCL-PEG-Mal

AbstractCarboxylic acid terminated poly(ε-caprolactone)s (PCL-COOHs) with narrow polydispersity were synthesized and coupled with poly(ethylene glycol) (HO–PEG–OH) to afford PCL-PEG–OH copolymers. The hydroxyl groups in the PCL-PEG–OHs were then converted to maleimide groups to afford maleimide terminated PCL-PEG-MALs that contained 70–90% maleimide functionality. Nanoparticles with maleimide functionality on their surfaces were prepared by impingement mixing. Particle sizes and size distributions were determined by dynamic light scattering. Conjugation of reduced glutathione with model maleimides and two MAL-functional nanoparticles was also demonstrated. The amount of accessible maleimide on the particle surface was measured using Ellman's reagent to range between ≈51–67%.咸阳pg电子娱乐游戏app 生态学作为一些物品:PCL-PEG-FolatePCL-PEG-BiotinPCL-GlucosePCL-g-PEIPCL-HeparinPCL-PEG-HeparinPCL-GalactosePCL-PEG-Galactose上文优秀文章资源的来源各大杂志期刊或医学文献,予以侵权案请电话联系.我册除!