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PCL-PEG-Mal共聚物的合成与功能化
发布时间:2025-07-22     作者:kx   分享到:
期刊论文:马来酰亚胺官能化聚(ε-己内酯)-嵌段-聚乙二醇(PCL-PEG-MAL):制成、微米科粒型成和硫醇共轭链接代码://onlinelibrary.wiley.com/doi/abs/10.1002/macp.200900025我:吉胜祥, 朱正熙, 托马斯·R·霍伊, 克里斯托弗·W·马科斯科节选:分解成了具备有窄多细化性的羧酸封的聚(ε-己内酯)(PCL-COOH),并将其与聚(乙二醇)(HO-PEG-OH)偶联,获取PCL-PEG-OH共聚物。第三将PCL-PEG-OH中的羟基转成为马来酰亚胺基团,获取含带70–90%马来酰亚胺官能团的马来酰亚胺封的PCL-PEG-MAL。凭借冲撞分层备制了表层具备有马来酰亚胺官能团的奈米科粒物。凭借的动态光散射检验粒级和粒级生长。还事实证明了复原谷胱甘肽与实体模型马来酰亚胺和两种类型MAL官能团奈米科粒物的紧密结合。运行Ellman化学制剂测定了科粒物表层可及马来酰亚胺的量,领域为≈51–67%。

PCL-PEG-Mal

AbstractCarboxylic acid terminated poly(ε-caprolactone)s (PCL-COOHs) with narrow polydispersity were synthesized and coupled with poly(ethylene glycol) (HO–PEG–OH) to afford PCL-PEG–OH copolymers. The hydroxyl groups in the PCL-PEG–OHs were then converted to maleimide groups to afford maleimide terminated PCL-PEG-MALs that contained 70–90% maleimide functionality. Nanoparticles with maleimide functionality on their surfaces were prepared by impingement mixing. Particle sizes and size distributions were determined by dynamic light scattering. Conjugation of reduced glutathione with model maleimides and two MAL-functional nanoparticles was also demonstrated. The amount of accessible maleimide on the particle surface was measured using Ellman's reagent to range between ≈51–67%.陕西pg电子娱乐游戏app 生态学提供数据相应的的产品:PCL-PEG-FolatePCL-PEG-BiotinPCL-GlucosePCL-g-PEIPCL-HeparinPCL-PEG-HeparinPCL-GalactosePCL-PEG-Galactose上方面方面原因多种杂志期刊或参考文献,见谅侵权案请取得在线留言都删掉!