论文参考文献：Palladium cubes with Pt shell deposition for localized surface plasmon resonance enhanced photodynamic and photothermal therapy of hypoxic tumors†作家：Wenxiang Gu ab, Zhiyuan Hua b, Zheng Li ab, Zhiheng Cai a, Wandong Wang a, Kaijin Guo b, Feng Yuan b, Fenglei Gao ORCID logo*a and Hongliang Chen期刊论文下载链接：//pubs.rsc.org/en/content/articlehtml/2022/bm/d1bm01406d内容提要：Multifunctional phototherapy nanoagents for imaging-guided synergistic photothermal therapy (PTT) and photodynamic therapy (PDT) are highly desirable in the field of solid tumor therapy. Nevertheless, the tumor microenvironment (TME) inherently associated with hypoxia significantly hampers the photodynamic effect of these multifunctional nanoagents. Herein, Pd nanocubes coated with an ultrathin Pt shell were prepared and further conjugated with fluorescein labeled and thiol functionalized polyethylene glycol (FITC-PEG-SH) (denoted as Pd@Pt-PEG). The deposition of a Pt shell on Pd nanocubes not only enhances the photothermal performance, exhibiting excellent hyperthermia outcomes and impressive photothermal (PT) imaging quality, but also leads to the formation of singlet oxygen (1O2) induced by plasmonic excitation. In the meantime, the catalytic activity of the Pt layer is enhanced by electronic coupling and the plasmonic effect, which induces the decomposition of endogenous overexpressed hydrogen peroxide (H2O2) in tumors to generate O2 for conquering TME and augmenting 1O2 generation for efficacious tumor cell apoptosis. The modification of FITC-PEG-SH improves the biocompatibility and provides outstanding fluorescence (FL) imaging properties. Upon NIR laser irradiation, Pd@Pt-PEG allows in situ O2 generation and dual-mode imaging-guided synergistic PTT/PDT that effectively kills hypoxic tumor cells, which makes it a promising nanotherapeutic agent for enhanced tumor therapy.

用作激光散斑进行的携手光热制疗（PTT）和光的动力机制疗（PDT）的多特点光疗微米级剂在实体化瘤制疗业务领域受迎接。同时，与异星工厂当下的相应的良性肿瘤微学习环境（TME）明显障碍了等多特点微米级口服药的光的动力机效用。在，制取了涂有超薄型Pt壳的Pd微米级万立方米体，齐头并进1步与荧光素标上和巯基官能化的聚乙二醇（FITC-PEG-SH）（说明为Pd@Pt-PEG).Pt壳在Pd微米级万立方米体上的磨合不光强化了光性热能，表面出高品质的热有效时间果和让人觉得城市印象深入的光热（Pt）三维成像服务质量，并且还会造成等正离子体激起诱导性的单线态氧（1O2）的转变成。互相，Pt层的催化剂的作用催化活能力够智能电子合体和等阴阳离子体调节作用获得增进，这帮助了癌症中内源性过表达方式的过阳极氧化氢（H2O2）的溶解，导致O2以吸引TME，并加入1O2的导致以满足有效果的癌症内部凋亡。FITC-PEG-SH的渗透型增长了生物制品相融性，并带来了出众的荧光（FL）影像能力。在NIR脉冲光直射下，Pd@Pt-PEG能原位O2形成和双模影像引流的协同工作PTT/PDT，很好的消除缺氧游戏癌肿癌细胞，这使其已成为加强癌肿冶疗的有未来发展的微米冶疗剂。关于最新推荐：FITC-PEG-DTPAFITC-PEG-EstrogenFITC-PEG-LAFITC-PEG-MTXFITC-PEG-NiacinFITC-PEG-OPSSFITC-PEG-PCL(2K)FITC-PEG-PCL(5K)FITC-PEG-ProgestroneFITC-PEG-SCFITC-PEG-SilaneFITC-PEG-TretinoinICG-PEG-AlkyneICG-PEG-Biotin超过本文介绍来历种类刊物或参考文献，知悉侵犯知识产权请找咱们删除图片！