学术论文：Targeted folic acid-PEG nanoparticles for noninvasive imaging of folate receptor by MRI小说作品：Ting-Jung Chen, Tsan-Hwang Cheng, Yu-Chin Hung, Kuei-Tang Lin, Gin-Chung Liu, Yun-Ming Wang资料超链接：//onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.31752文献综述：The surface of superparamagnetic iron oxide nanoparticles (SPIO) with different molecular weight of poly(ethylene glycol) (PEG) and folic acid (FA) were synthesized. The SPIO-PEG-FA nanoparticles are well-dispersed and have good stability in various pH solutions. The lack of hysterestis and remanence at ambient temperatures is characteristic of superparamagnetic materials for SPIO-PEG-FA. The uptake by macrophage for SPIO-PEG-FA is lower than that of Feridex I.V. even at higher concentration. Internalization of SPIO-PEG-FA in targeted cells (KB cells) was observed by flow-cytometric analysis and in vitro MR imaging. The intensity change of positive KB cell tumor (−20 to 25%) is significantly lower than that of negative HT-1080 cell tumor from precontrast to postcontrast images of the tumor by in vivo MR imaging. These preliminary results demonstrated that SPIO-PEG-FA have the ability to target folate receptor.  

制作而成了不相同团伙量聚乙二醇（PEG）和孕妇叶酸（FA）的超顺带磁腐蚀铁nm激光束（SPIO）外表面。SPIO-PEG-FAnm激光束细化优良，在种种pH稀硫酸中有优良的稳固性。在自然环境温差下存在磁滞和剩磁是SPIO-PEG-FA的超顺永久磁铁原材料的显著特点。纵然在更为重要的氧化还原电位下，巨噬神经神经组织生殖细胞对SPIO-PEG-Fe的摄取量也高于Feridex I.V。确认流式神经组织生殖细胞神经神经组织生殖细胞术剖析和体内MR三维成像留意SPIO-PEG-FA在靶神经神经组织生殖细胞（KB神经神经组织生殖细胞）中的内化。按照人体内MR成相，从恶性癌肿的造影前画像到造影后画像，阳性反应KB组织恶性癌肿的力度发展（-20%至25%）特别高于呈阴性HT-1080组织恶性癌肿。这种进行結果认为，SPIO-PEG-FA还具有靶向药物孕妇叶酸肾上腺素受体的业务能力。相应举荐：FITC-PEG-AzithromycinFITC-PEG-CHOFITC-PEG-DTPAFITC-PEG-EstrogenFITC-PEG-LAFITC-PEG-MTXFITC-PEG-NiacinFITC-PEG-OPSSFITC-PEG-PCL(2K)FITC-PEG-PCL(5K)FITC-PEG-ProgestroneFITC-PEG-SCFITC-PEG-SilaneFITC-PEG-TretinoinICG-PEG-Alkyne以上主要内容小文章主要内容收入特殊论文期刊或专著，深表歉意知识产权侵权请关联我们的删了！