期刊论文：In situ crystal growth of gold nanocrystals on upconversion nanoparticles for synergistic chemo-photothermal therapy小说家；Ruoyan Wei,a   Wensong Xi,b   Haifang Wang,b   Jinliang Liu,a   Torsten Mayr,c   Liyi Shia  and  Lining Sun医学文献跳转： 小结：A multifunctional cancer therapy nanocomposite was proposed and synthesized by linking the pH-responsive SH-PEG-DOX prodrug onto gold nanocrystals that were grown in situ on the surface of upconversion nanoparticles (UCNPs). In the structure of the SH-PEG-DOX prodrug, a hydrazone bond was utilized for subsequent pH-responsive drug release in the intracellular acidic microenvironment of cancer cells. This innovative assembly method is facile and mild, and can be used to obtain nanocomposites of UCNPs and gold, which show excellent photostability and biocompatibility. The final UCNPs@Au-DOX nanocomposites offer efficient treatment effects in vitro under irradiation with an 808 nm laser due to the synergistic effect of chemotherapy and photothermal therapy. In addition, the UCNPs@Au-DOX nanocomposites show excellent intracellular locating ability via upconversion luminescence (UCL) imaging with Er3+ ions and magnetic resonance imaging (MRI) with Gd3+ ions, indicating that they have potential as a visual tracking agent in cancer treatment. Therefore, the presented bioimaging-guided multifunctional synergistic therapy nanocomposites are promising tools for imaging-guided cancer therapy.

给出并结合了了种全自动键*症奈米和好材质，将pH相应性SH-PEG-DOX前药链接到原位生长期在上流量转化奈米小粒（UCNP）表面上的金奈米納米线上。在SH-PEG-DOX前药的空间结构中，巧用腙键在*症癌癌人体细胞的癌癌人体细胞内弱酸性微生态环境中去马上又的pH相应性制剂脱离。各种去创新的拆装方法步骤十分简单清新，需用于荣获UCNP和金的奈米和好材质，彰显出表现出色的光不稳性和怪物技术相匹配性。冠军赛UCNPs@Au-DOX因为手术和光热诊疗方法的协同作战作战意义，奈米和好材质在808nm二氧化碳激光灯照下到身体具备了可行的诊疗方法效用。凡此种种UCNPs@Au-DOX奈米和好材质能够 Er3+阳铝离子的上转变成亮光（UCL）影像和Gd3+阳铝离子的磁震动影像（MRI）彰显出表现出色的癌癌人体细胞内标记技能，表示这些在*症诊疗方法中兼有隐藏的的视觉效果追踪剂。故此，所给出的怪物技术影像层面全自动键协同作战作战诊疗方法奈米和好材质是影像层面*症诊疗方法的有前景的专用工具。重要性推介：ACA-PEG-SHSH-PEG-OHAC-PEG-SHAlKyne-PEG-SHMA-PEG-SHN3-PEG-SHSH-PEG-BiotinFmoc-NH-PEG-SH上面一篇文章方面起源种类期刊杂志或资料，予以侵犯著作权请链接咱们删了！