文章：网站优化药材传输：利用 31P 和 2H NMR 光谱分析定性分析 DLin-KC2-DMA/二硬脂酰磷脂酰丝氨酸链接搜索：//summit.sfu.ca/item/15257小编：林赛·T·阿奇博尔德逊张迪周克进李桑明刘帅肖恩·A·迪利亚德卢卡斯·法比亚克苏曼塔·查特四平市玉轩丹尼尔·J·西格瓦特*节选：脂质纳米技术颗料 (LNP) 于进行内吞效用和后来的内体施放将 siRNA 递送入肝组织細胞核。根据 99% 的 LNP 是进行内吞效用被组织細胞核吸收率的，如此就 1% 的 siRNA 真实被施放到组织細胞核质中。想要改善 LNP 与内体膜结合在一起还有弄坏的有效率性，主要包括 2H 和 31P NMR 光谱图法表现了由 1:1 摩尔比的阴阴阳铝离子脂质 1,2-二硬脂酰(d70)-sn-甘油-3-[磷酸-L-丝氨酸] (DSPS-d70) 和阳阴阳铝离子脂质 DLin-KC2-DMA 組成的模式体制的动物物理性特质。但是表示，该模式体制从两层玻璃相向倒六角相 (HII) 的相变受气温、pH 值和盐氧浓度的影向。荣获了序主要参数生长图，探求了DSPS-d70在两层玻璃膜和HII相中酰基链运功的程度上。他们但是有益于为换算摸拟同时*终整合的LNP定制作为借鉴。

Lipid nanoparticles (LNPs) are used to deliver siRNA to hepatocytes via endocytosis and subsequent endosomal release. With 99% of the LNPs taken up by the cell via endocytosis, only 1% of the siRNA is actually released into the cell cytosol. To improve the effectiveness of LNPs association with and disruption of endosomal membranes, the biophysical properties of a model system composed of 1:1 molar ratio of anionic lipid 1,2-distearoyl(d70)-sn-glycero-3-[phospho-L-serine] (DSPS-d70) and the cationic lipid DLin-KC2-DMA are characterized by 2H and 31P NMR spectroscopy. The bilayer to inverted hexagonal (HII) phase transition of the model system was shown to be influenced by temperature, pH and salt concentration. The order parameter profiles are obtained, revealing the extent of acyl chain movement of DSPS-d70 in bilayer and HII phases. The results help provide insights into computational simulation and eventually optimized LNPs design.西安市pg电子娱乐游戏app 动物提供了涉及到的护肤品：DSPE-NHSDSTAP (18:0)DSPE-PEG-SHCy3-DPPEDSPE-PEG-HADPPE-PEG-N3Cy7-DOPE超过优秀文章信息来源地几大类中文核心期刊或参考文献，如无侵权行为请保持联系企业删去！