参考文献：提高药物治疗输送机：按照 31P 和 2H NMR 光谱分析分析方法 DLin-KC2-DMA/二硬脂酰磷脂酰丝氨酸外链：//summit.sfu.ca/item/15257笔者：林赛·T·雷德里克逊张迪周克进李桑明刘帅肖恩·A·迪利亚德卢卡斯·法比亚克苏曼塔·查特吉林市玉轩丹尼尔·J·西格瓦特*节选：脂质纳米级粉末 (LNP) 主要用于顺利选择内吞用途和接着随后的内体尽情移除将 siRNA 递送回肝组织细胞系核。可能 99% 的 LNP 是顺利选择内吞用途被组织细胞系核吸引的，故而只能 1% 的 siRNA 实打实被尽情移除到组织细胞系核质中。要提高自己 LNP 与内体膜结合起来下列关于破裂的有效果性，选择 2H 和 31P NMR 光谱分析法定量分析了由 1:1 摩尔比的阴铁化合物脂质 1,2-二硬脂酰(d70)-sn-甘油-3-[磷酸-L-丝氨酸] (DSPS-d70) 和阳铁化合物脂质 DLin-KC2-DMA 构成的的绘图组织体制的生物体力学形态。的报告阐明，该绘图组织体制从多层相向倒六角形相 (HII) 的相变受温暖、pH 值和盐氧化还原电位的干扰。可以获得了序指标布置图，探求了DSPS-d70在多层膜和HII相中酰基链运功的因素。以下的报告促进企业为运算模以并且*终改进的LNP设计制作出示基准。

Lipid nanoparticles (LNPs) are used to deliver siRNA to hepatocytes via endocytosis and subsequent endosomal release. With 99% of the LNPs taken up by the cell via endocytosis, only 1% of the siRNA is actually released into the cell cytosol. To improve the effectiveness of LNPs association with and disruption of endosomal membranes, the biophysical properties of a model system composed of 1:1 molar ratio of anionic lipid 1,2-distearoyl(d70)-sn-glycero-3-[phospho-L-serine] (DSPS-d70) and the cationic lipid DLin-KC2-DMA are characterized by 2H and 31P NMR spectroscopy. The bilayer to inverted hexagonal (HII) phase transition of the model system was shown to be influenced by temperature, pH and salt concentration. The order parameter profiles are obtained, revealing the extent of acyl chain movement of DSPS-d70 in bilayer and HII phases. The results help provide insights into computational simulation and eventually optimized LNPs design.渭南pg电子娱乐游戏app 生物技术提供数据相关联新产品：DSPE-NHSDSTAP (18:0)DSPE-PEG-SHCy3-DPPEDSPE-PEG-HADPPE-PEG-N3Cy7-DOPE以内稿件东西种类多种杂志期刊或论文，如果发现侵犯知识产权请结合企业卸载！