参考文献：Development of PLGA-PEG-COOH and Gelatin-Based Microparticles Dual Delivery System and E-Beam Sterilization Effects for Controlled Release of BMP-2 and IGF-1小说作者：Yan Bai, Seyedsina Moeinzadeh, Sungwoo Kim, Youngbum Park, Elaine Lui, Hua Tan, Weiling Zhao, Xiaobo Zhou, Yunzhi Peter Yang论文参考文献微信链接： 引言：A poly(lactic-co-glycolic acid)-poly(ethylene glycol)-carboxyl (PLGA-PEG-COOH) and gelatin-based microparticles (MPs) dual delivery system for release of bone morphogenetic protein-2 (BMP-2) and insulin-like growth factor-1 (IGF-1) is developed. The delivery system is characterized based on its morphology, loading capacity, encapsulation efficiency, and release kinetics. The effects of electron beam (EB) sterilization on BMP-2 and IGF-1-loaded MPs and their biological effects are examined. The synergistic effect of a controlled dual release of BMP-2 and IGF-1 on osteogenesis of human mesenchymal stem cells (MSCs) is evaluated. Encapsulation efficiency of growth factors into gelatin and PLGA-PEG-COOH MPs is in the range of 64.78% to 76.11%. E-beam sterilized growth factor delivery systems are effective in significantly promoting osteogenesis of MSCs, although E-beam sterilization decreases the bioactivity of growth factors in MPs by ≈22%. BMP-2 release behavior from gelatin MPs/PEG hydrogel shows a faster release (52.7%) than that of IGF-1 from the PLGA-PEG-COOH MPs/PEG hydrogel (27.3%). The results demonstrate that the gelatin and PLGA-PEG-COOH MPs-based delivery system can realize temporal release of therapeutic biomolecules by incorporating different growth factors into distinct microparticles. EB sterilization is an accessible method for sterilizing growth factors-loaded carriers, which can pave the way for implementing growth factor delivery in clinical applications.

开拓了一大种使用在发挥骨价值形式出现血清-2（BMP-2）和胰岛素样成长细胞因子-1（IGF-1）的聚乳酸-聚乙二醇-羧基（PLGA-PEG-COOH）和明胶基粒子（MP）双递送系统。递送软件系统的显著特点体现在其价值形式、环境下电阻力量、包封吸收率和施放能源学。研究方案了网上束（EB）高压蒸汽灭菌对环境下电阻BMP-2和IGF-1的MP的导致下列关于生物工程学滞后效应。评价了BMP-2和IGF-1的受控隐性施放对天地间充质干受损细胞（MSCs）成骨的协同工作做用。衍生要素在明胶和PLGA-PEG-COOH MP中的包封生产率在64.78%至76.11%中间。微电子设备束杀菌方法的衍生要素递送设备能合理有效同质性使得MSCs的成骨，尽量微电子设备束杀菌方法会使MP中衍生要素的生物制品活性氧减低约22%。明胶MPs/PEG水抑菌妇科凝胶的BMP-2增加出现象比PLGA-PEG-COOH MPs/PEG抑菌妇科凝胶的IGF-1增加出现象（27.3%）快些（52.7%）。没想到表达，体系结构明胶和PLGA-PEG-COOH MP的递送系统性就能够顺利通过将不一样的的出现细胞掺进不一样的的粒子来做到进行治疗性生物技术团伙的还增加出。一些举荐：IA-PEG-COOHAC-PEG-COOHAlKyne-PEG-COOHCOOH-PEG-EPOCOOH-PEG-MACOOH-PEG-N3CHO-PEG-COOHBiotin-PEG-COOHFmoc-NH-PEG-COOHBoc-NH-PEG-COOHMal-PEG-COOHSH-PEG-COOH上面的优秀文章知识來源各大期刊论文或论文资料，假如商标侵权请搞好关系他们去除！