您当前所在位置:首页 > 资讯信息 > 新品上市
基于mal-PEG-COOH偶联策略构建的高效MRI成像探针的合成与性能研究
发布时间:2025-07-17     作者:zyl   分享到:

文献:Prostate cancer targeted magnetic resonance imaging nanoprobes based on polyethylene glycol polyethyleneimine and superparamagnetic iron oxide

作著:周建华,黄绿,王伟伟,庞俊,邹艳,帅心涛,高新区论文参考文献地址://xueshu.baidu.com/usercenter/paper/show?paperid=c51dc88dae42acd9da7f55aeefd5bfbf&site=xueshu_se内容提要:A water-soluble copolymer of polyethylene glycol grafted polyethyleneimine (mPEG-g-PEI) was obtained by grafting branched polyethyleneimine (hy PEI) onto monomethyl ether polyethylene glycol (mPEG-OH). Superparamagnetic iron oxide nanoparticles (SPIO) were encapsulated by ligand exchange, and then functionalized polyethylene glycol (mal PEG COOH) was combined with activated prostate stem cell antigen (PSCA) monoclonal single chain antibody to obtain a targeted magnetic resonance imaging nanoprobe for prostate cancer cells Research has shown that the particle size of polyethylene glycol grafted polyethyleneimine (mPEI-g-PEG-SPIO) loaded with superparamagnetic iron oxide nanoparticles is about 50nm, which can significantly improve the specific delivery efficiency to prostate cancer cells, thereby significantly reducing the T2 signal intensity of magnetic resonance imaging (MRI) of prostate cancer cells and enhancing the recognition efficiency of prostate cancer. It may become a new nano probe for early diagnosis of prostate cancer MRI or a visible nucleic acid delivery carrier in gene therapy

mal-PEG-COOH

主要采用单甲基醚聚乙二醇(mPEG-OH)接枝支化聚氯氯丁二烯亚胺(hy-PEI),达到水可溶共 聚物聚乙二醇接枝聚氯氯丁二烯亚胺(mPEG-g-PEI),经由配体交互的方式邮包超顺剩磁四空气氧化的三铁納米级水物体(SPIO),再经由性能化的聚乙二醇 (mal-PEG-COOH)与纯化的靠前腺干癌血血细胞系抗原(PSCA)单克隆单链抗体阳性结合起来,获得了靠前腺*癌血血细胞系靶点核磁共鸣显像納米级电极.分析意味着,短路电流超顺 剩磁四空气氧化的三铁納米级水物体的聚乙二醇接枝聚氯氯丁二烯亚胺(mPEI-g-PEG-SPIO)的粒级约为50nm,能正相关增进对靠前腺*癌血血细胞系的特男人传送带生产率,从 而正相关地大幅度降低靠前腺*癌血血细胞系的核磁共鸣成相(MRI)T2电磁波抗弯强度,增进对靠前腺*的快速精确生产率,有将已成为是一种生活靠前腺*MRI最早的时候诊断报告环保型納米级电极亦或是DNA 治愈中是一种生活MRI见到的核酸传送带的载体.有关的安利:PEI-PEG-SHPEI-PEG-cRGDPEI-PLGAPEI-PLAPEI-PCLPEI Hyaluronate (PEI-HA)PEI-DextranPEI-ChitosanmPEG-PCL-PEIX-PEI-Y 超过一篇文章信息内容來源特殊杂志或论文参考文献,若有侵权案请电话联系他们删去!