基于4-arm-PEG-MAL构建水凝胶的缓释性能与生物相容性
论文参考文献:对于Diels-Alder发生反应的可注塑控释水凝胶的作用的制法名词解释物理质地小说作品:李聪聪,陈道远,李明慧,张文,张蓬,孙考祥论文资料链接转换: 绪论:The aim of this study was to prepare an injectable sustained release hydrogel through drug polymer coupling model and Diels Alder click reactionPuerarin hyaluronic acid coupling compound (PUE-HA) was prepared by connecting puerarin and hyaluronic acid through amide bond. PUE-HA and 4-arm maleimide polyethylene glycol (4-arm PEG-MAL) were crosslinked through Diels Alder click reaction to prepare injectable sustained-release hydrogel (PUE-HA-PEG) Compared with 1Furan/1MI and 1Furan/2MI hydrogels, the gelation time of 1Furan/4MI hydrogels can be shortened to 1 min. With the increase of MI ratio, the hydrogels have lower degradation rate (21 day degradation rate is less than 60%), better mechanical properties, and more obvious drug release effectThe experimental results show that the ratio of Furan/MI has a significant impact on the physical and chemical properties of injectable sustained-release hydrogels