期刊论文：聚乙二醇化壳聚糖-氟尿嘧啶偶合物的备制及身体外释放出来探究著者：段萍萍，关鹏程，朱亮医学文献地址： Objective: To synthesize PEGylated chitosan fluorouracil conjugate (5-FU-CS-mPEG) and investigate its in vitro release propertiesMethod: Carboxylated monomethoxypolyethylene glycol (mPEG COOH) was reacted with chitosan (CS) to prepare polyethylene glycol monomethyl ether modified chitosan (mPEGCS), which was then coupled with chloroacetic acid modified fluorouracil (FUA) in the presence of 1-ethyl - (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC · HCl)/N-hydroxysuccinimide (NHS) to form the target product 5-FU-CS-mPEG; Characterize the structure using UV, 1H-NMR, FT-IR; UV method for calculating prodrug loading; Using dynamic dialysis method to study prodrug release rateAs a result of structural confirmation, 5-FU-CS-mPEG was successfully synthesized; The degree of substitution of mPEG was calculated to be 12.31% by 1H-NMR; The drug loading capacity is 4.83%; The cumulative release of macromolecular prodrug at 120 hours is 57% Conclusion: 5-FU-CS-mPEG has a certain sustained release effect

的目的分解聚乙二醇化壳聚糖-氟尿嘧啶偶合物(5-FU-CS-mPEG),并考量其离体释放出性能指标.方式方法以羧基化单甲氧基聚乙二醇(mPEG-COOH)与壳聚糖(CS)发生反应制备聚乙二醇单甲醚改善壳聚糖(mPEGCS),再与经氯乙酸修饰语的氟尿嘧啶(FUA)在1-乙基-(3-二甲基氨基丙基)碳酰二亚胺酸洗盐(EDC·HCl)/N-羟基虎珀酰亚胺(NHS)介导下与CS偶联,转化成对象产品5-FU-CS-mPEG;用UV,1H-NMR,FT-IR对设计参与探析方法;UV法计算出前药载药量;用于的动态透析法探析前药挥发度.最后经成分确证,好镶嵌了5-FU-CS-mPEG;经1H-NMR算起mPEG的加入度为12.31%;载药量为4.83%;大生物大分子前药在120 h的减少增加量为57%.依据 5-FU-CS-mPEG享有千万的控释反应.有关的比较适合：NHS-PEG-COOHNHS-PEG-RGDOPSS-PEG-NHSPCL(5K)-PEG-NHSPh-PEG-NHSPLGA(20K)-PEG-NHSPLGA(5K)-PEG-NHSY-shape-PEG-NHS4-ArmPEG-(3Alkyne-1NHS)4-ArmPEG-(3Biotin-1NHS)8-ArmPEG-(2ARM-NHS,6ARM-Biotin)Biotin-PEG-NHSBiotin-PEG4-S-S-NHSmPEG-SS-NHSNHS-PEG-NHSPDLLA(5K)-PEG-NHS不低于好的文章信息内容种类几大类中文核心期刊或资料，告之侵犯商标权请联络当我们全部删除！