mPEG-COOH衍生物在α-玉米醇溶蛋白修饰中的应用研究
学术论文:mPEG接枝α-甜玉米醇溶核蛋白聚合反应物还有准备形式编辑:宋镕光,石彤非,李帆资料外部链接: 内容提要:The present invention relates to an mPEG grafted alpha zein polymer and its preparation method, which solves the technical problem of using zein as a coating material for drugs and nutrients, which is not conducive to controlling drug release and uniform particle size distribution The polymer was first prepared by reacting mPEG with succinic anhydride to obtain mPEG COOH; Then, mPEG COOH was reacted with α - zein to prepare mPEG grafted α - zein polymer The mPEG grafted alpha zein polymer prepared by the method of the present invention can form stable and uniformly sized microspheres (particle size between 80-100nm) after dissolving in water, which are smaller than the particle size of mixed zein and can improve the controlled release and bioavailability of hydrophobic drugs and nutrients