宝贝标题效果型聚乙二醇化壳聚糖纳米级科粒的化学合成和定量分析小说作品肖巨颖; 赵霞; 林园; 苏朝晖期刊论文下载链接：//openurl.ebsco.com/EPDB%3Agcd%3A14%3A17421374/detailv2?sid=ebsco%3Aplink%3Acrawler&id=ebsco%3Adoi%3A10.19894%2Fj.issn.1000-0518.240425&link_origin=none绪论：In the present study, Carboxyl and azide terminated polyethylene (N3-PEG-COOH) with different relative molecular mass of 500 and 1000 were grafted onto the chitosan (CS) backbones through amide reaction, followed by the preparation of chitosan-polyethylene glycol (CS-PEG) nanoparticles with controllable size and zeta potential via sodium tripolyphosphate (TPP) ionotropic gelation. Characterized by Fourier transform infrared spectrometer (FT-IR), nuclear magnetic resonance spectroscopy (NMR) and thermal gravimetric analyzer (TGA) confirmed the successful incorporation of PEG, and the structures of the nanoparticles were analyzed by transmission electron microscopy (TEM) and nanoparticle size and zeta potential analyzer. The results demonstrated that when m (CS) ∶m (TPP) is 3.33∶1, CS nanoparticles show excellent structural stability. Based on this, increasing the PEG grafting density further reduces the particle size and surface potential of CS-PEG nanoparticles. Moreover, the chemical reactivity of azide in CS-PEG nanoparticles was proved by the click reaction with alkyne-modified fluorescent molecule (5-FAM-alkyne), showing their potential as platform for target drug delivery, fluorescent probes and other biomedical applications.

在本研究分折中，借助酰胺症状将相比原子核水平为500和1000的羧基和叠氮封终端的聚丁二烯（N3-PEG-COOH）接枝到壳聚糖（CS）骨架子上，其次借助三聚磷酸钠（TPP）化合物抑菌凝胶化制作尽寸和ζ电极电势可控硅调光的壳聚糖-聚乙二醇（CS-PEG）奈米级级颗粒。借助傅里叶变幻红外光谱仪仪仪（FT-IR）、核磁震荡光谱仪仪（NMR）和热重分折仪（TGA）的表现查证了PEG的成就参入，并借助散射网络体视显微镜（TEM）和奈米级级颗粒尽寸和ζ电极电势分折仪分折了奈米级级颗粒的结构的。成果表达，当m（CS）∶m（TPP）为3.33∶1时，CS微米水粒子主要表现出出众的型式增强性。依托于此，延长PEG接枝强度进步降低了了CS-PEG微米小粒的粒度分布和接触面电位差。然而，根据与炔烃突显的荧光分子式（5-FAM-炔烃）的点一下现象，证明信了叠氮化物在CS-PEG微米小粒中的有机化学现象性，表明了它看做靶向疗法肿瘤药物递送、荧光检测器和其他生态学中医学应用软件app的优势。关联强烈推荐：COOH-PEG-HZCOOH-PEG-SSPLA(2K)-PEG-COOHPDLLA(5K)-PEG-COOHCOOH-PEG-PLA(10K)PLGA(8K)-PEG-COOHNO2-Bn-PEG-COOHDA-PEG-COOHPLGA(40K)-PEG-COOHPLGA(15K)-PEG-COOHCOOH-PEG-NH2.HClPLGA(1K)-PEG-COOHCOOH-PEG-CH2CH2COOtBu往上文章主要内容主要内容来源地多种期刊杂志或论文资料，如果版权侵权请联络我国去除！