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SH-PEG-COOH自组装层提升皮质醇检测灵敏度
发布时间:2025-07-15     作者:zyl   分享到:
 论文参考文献:Salivary Cortisol Determination on Smartphone-Based Differential Pulse Voltammetry System小说家:by Jingjing Liu 1,2,3ORCID,Ning Xu 2,Hong Men 2ORCID,Shuang Li 1ORCID,Yanli Lu 1,Sze Shin Low 1,Xin Li 1,Lihang Zhu 1,Chen Cheng 1,Gang Xu 1 andQingjun Liu学术论文链接搜索: 英文论文:With the accelerated pace of life, non-invasive cortisol detection at the point of care (POC) is in high demand for personal health monitoring. In this paper, an ultrasensitive immunosensor using gold nanoparticles/molybdenum disulfide/gold nanoparticles (AuNPs/MoS2/AuNPs) as transducer was explored for non-invasive salivary cortisol monitoring at POC with the miniaturized differential pulse voltammetry (DPV) system based on a smartphone. Covalent binding of cortisol antibody (CORT-Ab) onto the AuNPs/MoS2/AuNPs transducer was achieved through the self-assembled monolayer of specially designed polyethylene glycol (PEG, SH-PEG-COOH). Non-specific binding was avoided by passivating the surface with ethanolamine. The miniaturized portable DPV system was utilized for human salivary cortisol detection. A series current response of different cortisol concentrations decreased and exhibited a linear range of 0.5–200 nM, the detection limit of 0.11 nM, and high sensitivity of 30 μA M−1 with a regression coefficient of 0.9947. Cortisol was also distinguished successfully from the other substances in saliva. The recovery ratio of spiked human salivary cortisol and the variation of salivary cortisol level during one day indicated the practicability of the immunosensor based on the portable system. 

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本诗探索性没事种用金奈米微粒/二塑炼钼/金奈米微粒(AuNPs/MoS2/AuNPs)作感测器器的超迅敏天然免疫感测器器,使用基本概念智力华为手机的小型的差分单脉冲伏安法(DPV)体统在POC采取非侵犯性口水皮艺醇数据监测。真皮醇抗原(CORT-Ab)与AuNPs/MoS2/AuNPs感知器的共价搭配是变现特定装修设计的聚乙二醇(PEG,SH-PEG-COOH)的自装设单双层变现的。变现用工业乙醇胺钝化漆层来不要非活性聊天搭配。小形一体式式DPV系统用做猿类吐液真皮醇判断。多种牛皮醇含量的一系电流量死机减轻,线性网络范围内为0.5-200 nM,探测限为0.11 nM,准确度度为30μA M−1,归回弹性系数为0.9947。牛皮醇也成功地与唾沫中的一些杂质判断开。加标人唾沫牛皮醇的出售率和唾沫牛皮醇横向在一天到晚内的变迁说明了因为携便式设备的免疫检测感应器器的实用型性。关于强烈推荐:SH-PEG-HZACA-PEG-SHSH-PEG-OHAC-PEG-SHAlKyne-PEG-SHMA-PEG-SHN3-PEG-SHSH-PEG-BiotinFmoc-NH-PEG-SHSH-PEG-NH2.HClSH-PEG-COOH左右小文章项目的来源各大中文核心期刊或医学文献,如无图片侵权请联系起来企业移除!