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SH-PEG-COOH修饰金纳米棒的合成及多模态信号增强应用研究
发布时间:2025-07-15     作者:zyl   分享到:
医学文献:Surface Functionalized Gold Nanorods: Tracking and Observing Live Cell via Three Optical Signals 小说家:Qiu, Xiaozhong; Wang, Yaling; Cui, Yanyan; Sun, Zhipeng; Liu, Ru; Huang, Wenhua; Zhao, Feng; Zu, Yan; Yuan, Hui; Chang, Xueling; Gao, and Xueyun学术论文联接: Surface functionalized gold nanorods (GNRs) with three optical signals and the ability to track and observe live cells was investigated. The Cetyltrimethyl Ammonium Bromide (CTAB) was used as the shape-directing agent to develop GNRs with uniform size and aspect ratio. The as-synthesized GNRs can strongly enhance the Raman signal of the attached MGITC on the GNRs. Polyethylene glycol (SH-PEG-COOH) and SH-PEG-FITC were attached with GNRs through ligand exchange with CTAB. They can stabilize the GNRs, reduce the cytotoxicity and provide fluorescence signal. A cell-penetrating peptide was covalently conjugated with SH-PEG-COOH to assist the GNRs to enter living cell. After cultured with the MCF-7 cells, the surfaced functionalized Au nanorods can enter the MCF-7 cells and be tracking with enhanced MGITC Raman signal, FITC fluorescence, and Rayleigh scatter signal.

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调查了有两类光讯号的表明作用化金奈米棒(GNR)及定位和探究活细胞膜的技能。用第十六烷基前三基溴化铵(CTAB)当做外形结果导向剂,设计出尺寸规格和众横比更加均匀的GNR。合成视频的GNR能够 热烈怎强GNR上粘接的MGITC的拉曼网络信号。聚乙二醇(SH-PEG-COOH)和SH-PEG-FITC实现与CTAB的配体互换与GNR连到。二者能能相对稳定GNR,下降血肿瘤血细胞致癌性并保证荧光数据。血肿瘤血细胞阻隔肽与SH-PEG-COOH共价融合,以鼓励GNR来到活血肿瘤血细胞。与MCF-7组织一齐锻炼后,外表面官能化的Au微米棒可能开启MCF-7组织,合用强化的MGITC拉曼卫星信号灯、FITC荧光和瑞利散射卫星信号灯通过跟踪定位。关于推存:SH-PEG-RGDSH-PEG-EPOGala-PEG-SHSH-PEG-NTASH-PEG-DASH-PEG-SCMDBCO-PEG-SHSH-PEG-NH-MethoxyphenoneSH-PEG-SCSH-PEG-HZACA-PEG-SHSH-PEG-OHAC-PEG-SHAlKyne-PEG-SH之内散文信息由来特殊杂志期刊或文献资料,如不抄袭请连系他们删出!