文献资料：Biotin-conjugated PEGylated porphyrin self-assembled nanoparticles co-targeting mitochondria and lysosomes for advanced chemo-photodynamic combination therapy†编辑：Baskaran Purushothaman , Jinhyeok Choi , Solji Park , Jeongmin Lee , Annie Agnes Suganya Samson , Sera Hong and Joon Myong Song论文参考文献链接代码：英文论文：The release pattern of DOX from the DOX@TPP–PEG–biotin self-assembled nanoparticles was evaluated by the dialysis method. In this experiment, the released sample was measured at different time points using HPLC. Fig. 2c shows the release of DOX from the self-assembled nanoparticles at 37 °C in different PBS media (pH 7.4 and pH 6.0), indicating desirable stability of the DOX@TPP–PEG–biotin SANs. After 24 h, the DOX released was only 30.0 ± 1.8% in the pH 7.4 PBS medium compared to that in the pH 6.0 PBS medium (65.4 ± 2.0%). These results indicate that under acidic conditions the DOX was released into the cellular medium. The sizes and zeta potentials in Fig. 2a and b showed no aggregation behavior at room temperature for five days at 37 °C, indicating that the self-assembled nanoparticles prepared in this study showed adequate stability.

DOX的解放策略DOX@TPP适用透析法对PEG-生物学素自制造奈米塑料再生颗粒采取了风险评估。在该实践中，适用HPLC在各个的时间点在线测量解放的印刷品。显视了在37°C下，在不相同的PBS有机溶剂（pH 7.4和pH 6.0）中，DOX从自按装纳米级物体中尽情释发好，得出结论DOX更具不稳判定性DOX@TPP–PEG–怪物素SAN。24小后，与pH 6.0 PBS的教育培养液的配制（65.4±2.0%）相对来说，pH 7.4 PBS的教育培养液的配制中尽情发出的DOX仅为30.0±1.8%。这一些的结果体现了，在偏酸必要条件下，DOX被发挥到肿瘤细胞致力于基中。图2a和b中的长宽高和ζ电势差在37°C的高温下重复三天不存在体现 出聚众情况，体现了本理论研究中准备的自組裝纳米级离子体现 出充足的稳定的性。有关系个性化推荐：PLGA(5K)-PEG-NHSY-shape-PEG-NHS4-ArmPEG-(3Alkyne-1NHS)4-ArmPEG-(3Biotin-1NHS)8-ArmPEG-(2ARM-NHS,6ARM-Biotin)Biotin-PEG-NHSBiotin-PEG4-S-S-NHSmPEG-SS-NHSNHS-PEG-NHSPDLLA(5K)-PEG-NHSPLGA(75:25)(5K)-PEG-NHSsulfo NHS-PEG-SS-PEG-NHS sulfo上述论文相关内容来源于各项杂志期刊或论文，见谅侵犯肖像权请链接大家删掉！