DSPE-PEG-RGD的合成与制备
文献资料:靶向药物递送包康普瑞塔汀A-4和阿霉素的RGD绘制脂质体代替**:里面和里面研究分析外部链接://www.sciencedirect.com/science/article/abs/pii/S0939641110000044做者:张逸飞,王建好,卞东彦,张 轩 ,李杰 节选:RGD–PEG-DSPE的聚合DSPE-PEG-RGD 的化学合成工艺如上所说 。对生理生理反应迟钝相混物在不一时期点的色谱剖析(图 1)阐明,在生理生理反应迟钝状态下,RGD 可以说充分花费。生理生理反应迟钝标准中约 50% 的 DSPE-PEG-NHS 复制粘贴量与 RGD 肽配合。所述有机物不可进一歩纯化就行了广泛用于化学合成脂质体。Synthesis of RGD–PEG-DSPEPreparation of DSPE-PEG-RGD was performed as described previously [12]. Chromatographic analysis of the reaction mixture at different time points (Fig. 1) showed that the RGD was consumed almost completely under the conditions of reaction. Around 50% of input DSPE-PEG-NHS in reaction system was conjugated with RGD peptide. The resulting product was then used for preparing liposomes without further purification.