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基于DSPE-PEG-RGD的siRNA靶向递送脂质体制备
发布时间:2025-07-14     作者:kx   分享到:
论文:创新型 RGD-脂质共轭遮盖脂质体广泛用于增强人网膜色素沉着上皮神经细胞中 siRNA 的递送地址://www.tandfonline.com/doi/full/10.2147/IJN.S24447#d1e278著者:陈成伟,卢大文,叶明公,萧嘉阳&蒋介石节选:合成图片一个多种多样新功能表性脂质DSPE-PEG-RGD,其型式为Arg(R)-Gly(G)-Asp(D)肽基与1,2-二硬脂酰-sn-甘油-3-磷酸工业乙醇胺-N-[马来酰亚胺(聚乙二醇)-2000]偶联。该脂质体广泛用于备制载siRNA的RGD-PEG化脂质体,以增強眼底黄斑色素沉积上皮肿瘤细胞对siRNA的摄取量。备制了分别为包含1 mol%和5 mol% PEG化脂质及及1 mol%和5 mol% RGD-PEG化脂质的多种多样脂质体。

DSPE-PEG-RGD

MethodsA novel functional lipid, DSPE-PEG-RGD, a Arg(R)-Gly(G)-Asp(D) motif peptide conjugated to 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine- N-[maleimide (polyethylene glycol)-2000], was synthesized for the preparation of siRNA-loaded RGD-PEGylated liposomes to enhance uptake of encapsulated siRNA in retinal pigment epithelial cells. Various liposomes, with 1 mol% and 5 mol% PEGylated lipid or 1 mol% and 5 mol% RGD-PEGylated lipid, were fabricated.昆明pg电子娱乐游戏app 生态学具备有关护肤品:DSPE-PEG-ACDSPE-PEG-OHDSPE-PEG-Anti-rat CC531mAb(二硬脂酰基磷脂酰乙酸乙酯胺-聚乙二醇-癌症靶向药物蛋白酶)DSPE-PEG-6-FAMDPPE-PEG-MalDSPE-PEG-DBCOFITC-iRGD-PEG-DSPEcRGD-PEG-N3及以上新闻稿件的内容来源地各样期刊杂志或论文参考文献,请谅解版权侵权请连续大家全部删除!