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Bi(mPEG-S-S)-TPE胶束的制备与表征
发布时间:2025-07-14     作者:zyl   分享到:
医学文献:AIE-Featured Redox-Sensitive Micelles for Bioimaging and Efficient Anticancer Drug Delivery诗人:by Wei Zhao 1,†,Zixue Li 1,†,Na Liang 2,*,Jiyang Liu 1,Pengfei Yan 1 andShaoping Sun 期刊论文图片链接:The drug-loaded Bi(mPEG-S-S)-TPE micelles were obtained as follows. At first, the Bi(mPEG-S-S)-TPE dispersion in distilled water was prepared. Then, the PTX in the acetone solution was added. After being sonicated for 3 min (on for 3 s and off for 2 s), the mixture was dialyzed (MWCO of 3500 Da) against distilled water for 2 h and further filtrated with a 0.45 μm filter to obtain the drug-loaded micelles. The micelles could be further freeze-dried and stored as a white powder.XRD analysis was used to analyze the crystalline characteristic of PTX in the micelles (Geigerflex, Rigaku Co., Tokyo, Japan). Data were collected from 5° to 50° with a step-scan mode. The dynamic light-scattering method was employed to determine the particle size and zeta potential of PTX-loaded micelles (Zetasizer Nano-ZS90, Malvern Instruments, Malvern, UK). The drug loading (DL) and encapsulation efficiency (EE) were calculated using Equations (2) and (3), respectively.

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Bi(mPEG-S-S)-TPE胶束的提纯与表现载药的Bi(mPEG-S-S)-TPE胶束下列获得了。应先,准备了Bi(mPEG-S-S)-TPE在减压蒸溜泥里的增溶体。第三,倒入异丙醇饱和溶液中的PTX。 1分钟的高周波工作(开起3秒,开启2秒)后,将搭配物用减压蒸溜水透析(MWCO为3500 Da)2几小时,第三用0.45μm油烟净化器器进一歩油烟净化器,有载药胶束。胶束能能进一歩冷冻冰箱烘干,并且以暗红色粉尘的的方式会自动储存。XRD深入数据分析分析于深入数据分析分析胶束中PTX的晶粒优点。用阶跃检测策略从5°到50°收藏数据分析。用信息光散射法判断PTX电流电阻胶束的粒度和ζ电势差(Zetasizer Nano-ZS90,Malvern Instruments,英国媒体Malvern)。分別的使用式子式(2)和(3)算起药物剂量电流电阻量(DL)和包封高效率(EE)。相关的网友推荐:Silane-PEG-BiotinLA-PEG-BiotinIA-PEG-BiotinBiotin-PEG-ACAN3-PEG-BiotinOPSS-PEG-BiotinBiotin-PEG-MalBiotin-PEG-SCMSH-PEG-BiotinBiotin-PEG-OHBiotin-PEG-NH2以内短文相关内容原因常见期刊论文或医学文献,假如有知识产权侵权请认识我们的误删!