论文资料：AIE-Featured Redox-Sensitive Micelles for Bioimaging and Efficient Anticancer Drug Delivery编辑：by Wei Zhao 1,†,Zixue Li 1,†,Na Liang 2,*,Jiyang Liu 1,Pengfei Yan 1 andShaoping Sun 资料外链：

The amphiphilicity of Bi(mPEG-S-S)-TPE makes it trend to self-assemble into micelles, with TPE aggregated to serve as the core and mPEG formed the shell. PTX could be loaded into the micelles due to the hydrophobic interaction. For the optimized PTX-loaded micelles, the particle size was 96 ± 3.9 nm, and PDI was 0.358. Notably, such size facilitates the particles to spontaneously aggregate in the tumor via the EPR effect, keep a low level of uptake by the RES, and minimize renal excretion [32]. Zeta potential measurement revealed the PTX-loaded micelles charged negative potential, with a value as high as −39.9 mV, which implied that there was repulsive force among the particles, and the micelles would exhibit excellent stability. Moreover, the negative charge would protect the micelles from recognition by the RES [33]. The drug loading and encapsulation efficiency were determined to be 6.8% and 74.8%, respectively.

To confirm the existing state of PTX in Bi(mPEG-S-S)-TPE micelles, XRD analysis was conducted. As observed from Figure 3A, PTX showed diffraction peaks in the 2θ range of 5° to 30°. The pattern of the physical mixture was the simple superposition of the diagrams of blank micelles and PTX. In contrast, the diagram of drug-loaded micelles was similar as the bare micelles without any crystalline peaks of PTX detected, which implied that PTX was loaded in the micelles.

负载PTX的Bi（mPEG-S-S）-TPE胶束的表征

Bi（mPEG-S-S）-TPE的两亲性使其人格缺陷于自制造成胶束，TPE聚众成核，mPEG建立壳。随着疏水之间影响，PTX可被调用到胶束中。针对于seo的PTX装载胶束，粒度分布为96±3.9nm，PDI为0.358。这般尺寸这会有利于粉末剂能够EPR滞后效应在良性肿瘤中组织化聚众，要保持RES的低摄入水准，并最高容许地极大减少肾脏排尿。Zeta电位差差量测界面显示，负荷PTX的胶束带负电位差差，其值自由高达-39.9 mV，这后果着粉末剂相互间会有排挤力，胶束将的表现出出色的不稳性。不但，负带电粒子将防护胶束不会受到RES的面部识别。载药量和包封率差别为6.8%和74.8%。关键在于核验PTX在Bi（mPEG-S-S）-TPE胶束中的有着动态，对其进行了XRD研究。PTX在5°至30°的2θ区域内提示出衍射峰。数学混合型物的形式是空缺胶束和PTX图的简洁重叠。相比的情况下的情况下，载药胶束的图与未检侧到任何PTX结晶体峰的裸胶束同类，这预兆着PTX被存储在胶束中。相关强烈推荐：AC-PEG-N3AlKyne-PEG-N3COOH-PEG-N3MA-PEG-N3N3-PEG-EPON3-PEG-OHN3-PEG-SHCHO-PEG-N3N3-PEG-NH2N3-PEG-SCMN3-PEG-Biotin超过论文信息内容收入多种期刊论文或医学文献，要是有图片侵权请关联我册除！