文献综述：Tumor-targeting and redox-sensitive micelles based on hyaluronic acid conjugate for delivery of paclitaxel小说作者：Jiyang Liu, Na Liang, […], and Shaoping Sun 参考文献外部链接： The clinical application of paclitaxel is limited due to its low solubility and severe side effects. A tumor-targeting and redox-sensitive paclitaxel-loaded micellar system could exhibit high drug solubility, excellent antitumor activity and low toxicity to normal tissues. An mPEG and hexadecanol-modified hyaluronic acid with disulfide bridges in the molecules (mPEG-S-S-HA-C16) was designed and synthesized. Using mPEG-S-S-HA-C16 as the carrier, the paclitaxel-loaded micelles were fabricated, and their physicochemical properties were studied deeply. Moreover, the antitumor evaluation of the paclitaxel-loaded micelles was conducted in vitro and in vivo. For the optimized paclitaxel-loaded mPEG-S-S-HA-C16 micelles, the average size and zeta potential were 168.6 nm and −38.2 mV, respectively. In vitro drug release study demonstrated the redox-sensitivity of the micelles that the encapsulated paclitaxel could be released rapidly in the presence of glutathione. MTT assay confirmed the low toxicity of the polymeric material itself and the excellent cytotoxicity of paclitaxel-loaded mPEG-S-S-HA-C16 micelles against MCF-7 cells. Moreover, the in vivo antitumor evaluation demonstrated the superior antitumor efficacy of the paclitaxel-loaded micelles. These results suggested that the paclitaxel-loaded mPEG-S-S-HA-C16 micelles held great promise for targeted delivery of paclitaxel.

短路电流紫杉醇的良性淋巴肿瘤靶点和氧化的恢复备份灵敏胶束体系能够 突出表现出高药品充分均匀的溶解性、非常好的良性淋巴肿瘤吸附性和对普通 组织结构的低毒素。方案并镶嵌一堆种原子中有带二硫键的mPEG和十五醇装饰的半透明质酸酶（mPEG-S-S-HA-C16）。以mPEG-S-S-HA-C16为形式，提纯了紫杉醇胶束，并对其化学特性通过了深入学习科研。 相对 升级优化的紫杉醇装载mPEG-S-S-HA-C16胶束，一般粒度分布和ζ电位差为168.6 nm和-38.2 mV。身体食用的药物发挥论述介绍信了胶束的被氧化回归特别辨别力和理性，即包封的紫杉醇在谷胱甘肽有下应该高效发挥。MTT法验证了汇聚物村料原本的低致癌性和紫杉醇电流mPEG-S-S-HA-C16胶束对MCF-7神经细胞膜的高品质神经细胞膜致癌性。等最终结果认为，电动机扭矩紫杉醇的mPEG-S-S-HA-C16胶束在紫杉醇的靶向疗法递送层面兼具很大的的行业前景。有关于引荐：mPEG-SS-COOHmPEG-COOHmPEG-CH2CH2COOHAlkene-PEG-COOHI-PEG-COOHNB-PEG-COOHc(RGDyK)-PEG-COOHPLGA(17K)-PEG-COOHPhosphoric acid-PEG-COOHCOOH-PEG-N+Me3PCL(2K)-PEG-COOHCOOH-PEG-SS-PEG-COOH往上本文的内容的来源各种各样期刊论文或文献综述，烦请版权侵权请找话题我们都刪除！