专著：Targeted delivery and triggered release of liposomal doxorubicin enhances cytotoxicity against human B lymphoma cells作著：T Ishida a 1, M.J Kirchmeier a 2, E.H Moase a, S Zalipsky b, T.M Allen 参考文献友链：

提要：Since CFE is expected to contain cytoplasmic and lysosomal enzymes, the leakage of the hydrophilic, membrane-impermeable dye HPTS from formulations exposed to CFE may mimic the process of destabilization, in an intracellular environment, of liposomes stabilized with either mPEG-DSPE or mPEG-S-S-DSPE. CFE was adjusted to pH 5.5, approximating the lysosomal pH of between 5 and 6.5 [37], [38]. DOPE formulations, or DOPE formulations with 3 mol% mPEG-S-S-DSPE, released their contents in CFE with half-lives of 1.7 h (Fig. 3A). The release rate in CFE of the DOPE formulation with 5 mol% mPEG-S-S-DSPE was considerably slower; only 40% of encapsulated dye was released over 24 h (Fig. 3A). All three DOPE/CHEMS formulations, with or without mPEG-S-S-DSPE, released HPTS rapidly in CFE at pH 5.5; this release was almost complete by 8 h (Fig. 3B). DOPE/CHEMS and DOPE/CHEMS/mPEG-S-S-DSPE formulations incubated in CFE adjusted to pH 7.4 released HPTS at much slower rates (data not shown).

致使CFE再创新高富含神经体细胞质和溶酶体酶，亲水性树脂、膜切不可进行渗透的颜料HPTS从爆漏于CFE的药物制剂中漏泄或者会摸拟用mPEG-DSPE或mPEG-S-S-DSPE安全的脂质体在神经体细胞内区域环境中的失稳全过程。将CFE调试至pH 5.5，使溶酶体pH值更加接近5至6.5。DOPE中药剂型或含有3 mol%mPEG-S-S-DSPE的DOPE中药剂型在CFE中宣泄其含磷量，半衰期为1.7小时英文。有效5mol%mPEG-S-S-DSPE的DOPE中药药中药制剂在CFE中的保持数率很明显速度慢；24个钟头内仅保持了40%的包封纺织染料。因此3种DOPE/CHEMS中药药中药制剂，不论会不会有效mPEG-S-S-DSPE，在pH 5.5的CFE泉河能高效保持HPTS；8个钟头后，保持近乎提交。在pH 7.4的CFE中孵育的DOPE/CHEMS和DOPE/CHEMS/mPEG-S-S-DSPE中药药中药制剂以慢得多的数率保持HPTS。关联推建：CLS-PEG-MalCLS-PEG-FACLS-PEG-SHCLS-PEG-NH2CLS-PEG-COOHCLS-PEG-SCmPEG-CLS8-ArmPEG-CLS4-ARMPEG-CLSCLS-PEG-CLSCY7-PEG-DSPEGalactose-PEG-Palmitic acid及以上软文的内容的来源各个学术期刊或论文参考文献，如遇侵犯知识产权请建立联系我国去除！