文献资料：Targeted delivery and triggered release of liposomal doxorubicin enhances cytotoxicity against human B lymphoma cells诗人：T Ishida a 1, M.J Kirchmeier a 2, E.H Moase a, S Zalipsky b, T.M Allen 论文的链接：

提要：DOPE liposomes can also be stabilized in the bilayer state by an amphiphile with bulky and/or charge-repulsing hydrophilic moieties [35]. CHEMS (cholesteryl hemisuccinate), which is net negatively charged at pH 7.4, has been widely used to stabilize DOPE in the bilayer state at neutral pH. Protonation of CHEMS at low pH (<6.0) accelerates the destabilization of DOPE vesicles by promoting the formation of the hexagonal (HII) phase [16], [36]. DOPE/CHEMS formulations without mPEG-DSPE had little leakage at pH 7.4, but rapidly released encapsulated dye at pH 5.5 (Fig. 2A). At pH 5.5 or 7.4 less than 10% leakage occurred over 24 h when these liposomes were stabilized with 5 mol% mPEG-DSPE (Fig. 2A). In the presence of DTT, DOPE/CHEMS liposomes containing 5 mol% mPEG-S-S-DSPE had a release half-life of approximately 8 h at pH 5.5, while little release occurred at pH 7.4 (Fig. 2B); DTT treatment of DOPE/CHEMS liposomes stabilized with 3 mol% mPEG-S-S-DSPE resulted in intermediate leakage rates

DOPE脂质体也能够利用有着视诊积和/或电势排挤亲水这部分的两亲性物在两层壮态下可靠可靠。CHEMS（胆固醇升高半蜜腊酸盐）在pH 7.4时带净负电势，已被比较广泛于在中性化pH下可靠可靠两层壮态的DOPE。CHEMS在低pH（<6.0）下的质子化顺利通过增强六方（HII）相的导致降速了DOPE囊泡的失稳。中含mPEG-DSPE的DOPE/CHEMS药物制剂在pH 7.4时近乎没了泄露，但在pH 5.5时较快放出包封活性染料。

在pH 5.5或7.4下，当这些脂质体用5mol%mPEG-DSPE稳定时，24小时内发生的泄漏小于10%。在DTT存在的情况下，含有5mol%mPEG-S-S-DSPE的DOPE/CHEMS脂质体在pH 5.5时的释放半衰期约为8小时，而在pH 7.4时几乎没有释放（图2B）；用3mol%mPEG-S-S-DSPE稳定的DOPE/CHEMS脂质体的DTT处理导致中等泄漏率。

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