医学文献：mPEG-DPPE/CaP奈米粒子束合力递送雷公藤内酯醇和姜黄素于子宫卵巢癌靶点*链接转换：//www.ingentaconnect.com/contentone/asp/jbn/2018/00000014/00000010/art00008作家：刘雷； 熊晓媛; 沉明; 茹、丹； 高培; 张翔宇; 黄灿; 孙英； 李、何； 段友容节选：雷公藤内酯醇已被查证兼有*癌升值空间并被非常广泛用在*癌钻研。尽管，肾肝致癌性受限制了其在癌症复发*中的利用。本钻研开放另外一种经由mPEG-DPPE/磷酸钙的中成药递送系統，共阻抗雷公藤内酯醇和姜黄素（TP和Curc-NPs）。经由测算中成药互不意义弹性系数（CDI）来确定好五种中成药的绝佳质量密度。当雷公藤内酯醇质量密度为25.22 ng/mL，姜黄素质量密度为6.62 μ g/mL时，五种中成药对SKOV-3*血肿瘤細胞达标最大化的协作作战伤害性意义。利用超声检杳乳状液法治社会备TP和Curc-NPs。流式肿瘤細胞术血肿瘤細胞术探测結果提示 ，TP和Curc-NPs可将血肿瘤細胞周期公式阻滞于S期和G2/M期，并症状出强些的引诱血肿瘤細胞凋亡技能。血肿瘤細胞内灵活性氧(ROS)探测結果显示姜黄素能下降雷公藤甲素所致的血肿瘤細胞内ROS标准。qTR-PCR探测热晕厥血清(HSP)mRNA标准,結果显示TP和Curc-NPs均能下降HSP70mRNA标准,而对HSP90mRNA标准无显著下降意义。小动物进行实验证明信TP和Curc-NPs兼有非常好的较果,抑瘤率达68.78%;病理学检杳結果显示微米粒对最重要脏器无显著致癌性意义。上述情况所论,TP和Curc-NPs在身体外对子宫卵泡癌均有协作作战意义,姜黄素可以性经由*硫化应激状态意义减缓雷公藤甲素所致的致癌性,TP和Curc-NPs可以性是另外一种有行业前景的子宫卵泡癌*措施。

Triptolide has proven to possess anticancer potential and been widely used for anti-cancer research. However, the liver and kidney toxicity has limited its application in cancer treatment. In this study, a drug delivery system based on mPEG-DPPE/calcium phosphate was developed to co-load triptolide and curcumin (TP and Curc-NPs). The coefficient of drug interaction (CDI) was calculated to determine the optimal concentration of the two drugs. When the concentration of triptolide was 25.22 ng/mL and the concentration of curcumin was 6.62 μg/mL, the two drugs reached the maximum synergistic killing effects on SKOV-3 tumor cells. The TP and Curc-NPs was prepared using ultrasonic emulsification. Flow cytometry results revealed that the TP and Curc-NPs arrested cell-cycle in the S and G2/M phases and exhibited a strong ability to induce apoptosis. Intracellular reactive oxygen species (ROS) results indicated that curcumin could reduce the intracellular ROS level caused by triptolide. The mRNA levels of heat shock protein (HSP) were detected by qTR-PCR and the results showed that the TP and Curc-NPs could lower the HSP70 mRNA level while could not reduce the HSP90 mRNA level. The animal experiments demonstrated the favorable curative effects of the TP and Curc-NPs, and the tumor inhibition rate reached 68.78%. The results of the pathological examinations demonstrated that the nanoparticles had no significant toxic effects on important organs. In conclusion, the TP and Curc-NPs exerted synergistic effects on ovarian cancer in vitro and in vivo, and the toxicity caused by triptolide may be reduced by curcumin through anti-oxidative stress effects. The TP and Curc-NPs could be a promising strategy for ovarian cancer.广州pg电子娱乐游戏app 生物制品打造相关内容企业产品：DSPE-PEG-MalDSPE-PEG-Fab’of C225 mAb(cetuximab)（二硬脂酰基磷脂酰无水乙醇胺-聚乙二醇-*靶点蛋白质)iRGD-PEG-SHM2pep-PEG-DSPEDSPE-PEG-Fab’of matuzumab or C225（二硬脂酰基磷脂酰乙酸乙酯胺-聚乙二醇-*靶向治疗血清)DSPE-PEG-nano goldiRGD-PEG-N3DSPE-PEG-lactoferrinDSPE-PEG-HACCK8-PEG-DSPE上面稿件信息种类各种刊物或参考文献，予以侵犯著作权请找公司删掉！