参考文献:Optimization of tumor-selective targeting by basic fibroblast growth factor-binding peptide grafted PEGylated liposomes小说作品：Takeshi Terada, Miki Mizobata, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida学术论文跳转： 绪论：KRTGQYKLC (bFGF), is recognized by fibroblast growth factor (FGF) receptor (FGFR) via binding to basic FGF (bFGF), and is capable of being used for drug delivery to tumors highly expressing FGFR and bFGF. However, although the binding and uptake of the liposomes (bFGFp-liposomes) modified by the peptide increased in the presence of bFGF, the modification induced non-specific uptake. To overcome this problem, here, we prepared bFGFp-liposomes including mPEG-DSPE. The 5 and 10% mPEG5000/ and 10% mPEG3000/bFGFp-liposomes reduced most of the interaction with erythrocytes and the uptake by macrophages, suggesting the sustained blood circulation of bFGFp grafted PEGylated liposomes. Furthermore, 10% mPEG3000/bFGFp-liposomes produced a significant increase in uptake in NIH3T3, A549, and B16BL6 cells with the expression of FGFR following pre-incubation with bFGF, but no increase in CHO-K1 cells lacking FGFR expression. Taken together, these results lead us to believe that bFGFp grafted PEGylated liposomes possess the functions of both PEGylated stealth liposomes and the tumor-targeting liposomes. 

肽KRTGQYKLC（bFGF）借助与酸碱性FGF（bFGF）结合起来被成化学纤维内部生长期细胞因子（FGF）蛋白激酶（FGFR）设别，然而够用到向高理解FGFR和bFGF的良性肿瘤递送药。尽可能，尽可能在bFGF具有下，肽体现的脂质体（bFGFp脂质体）的组合和摄入扩大，但该体现介导了非非特异聊天摄入。从而缓解该困难，我门来到里化学合成了有效mPEG-DSPE的bFGFp脂质体。5%mPEG5000/和10%mPEG3000/bFGFp脂质体可以减少了与红肿瘤癌细胞的大部件能够 影响和巨噬肿瘤癌细胞的摄入，证实bFGFp接枝PEG化脂质体的继续鲜血无限循环。虽然，10%mPEG3000/bFGFp脂质体在与bFGF预孵育后，在传达FGFR的NIH3T3、A549和B16BL6細胞中相关性增强了摄食，但在匮乏FGFR传达的CHO-K1細胞中沒有增强。以上所讲，这样的导致使我信自己bFGFp接枝的PEG化脂质体兼有PEG化无痕脂质体和癌肿靶向药物脂质体的效果。相关分享：DSPE-PEG-NTA-NIDSPE-PEG-PCLDSPE-PEG-PDPDSPE-PEG-PEIDSPE-PEG-PLADSPE-PEG-PLGADSPE-PEG-ProgestroneDSPE-PEG-RGDDSPE-PEG-SCDSPE-PEG-SCMDSPE-PEG-SG超过句子文章由来各种类型期刊杂志或论文，假如有知识产权侵权请去联系大家全部删除！