论文资料：Rehydrated Lyophilized Rifampicin-Loaded mPEG–DSPE Formulations for Nebulization小说作品：Juma Masoud Abdulla Abdulla, Yvonne Tze-Fung Tan & Yusrida Darwis论文资料下载链接： 文献综述：Rifampicin-loaded nanoparticles were prepared using two different molecular weights of poly-(ethylene oxide)-block-distearoyl phosphatidyl-ethanolamine (mPEG2000–DSPE and mPEG5000–DSPE) polymers. Particle sizes of all formulations studied were in the range of 162–395 nm. The entrapment efficiency (EE) was not affected by the copolymer’s molecular weight, and the highest EE (100%) was obtained with drug to copolymer ratio of 1:5. The differential scanning calorimetry (DSC) thermograms showed Tg of rifampicin-loaded PEG–DSPE nanoparticles that shifted to a lower value, indicating entrapment of rifampicin in polymer matrix. The Fourier transformed infrared spectra revealed no chemical interactions between the drug and both copolymers. The in vitro drug release from the formulations occurred over 3 days and followed first-order release kinetic and Higuchi diffusion model. The nebulization of rehydrated lyophilized rifampicin mPEG–DSPE formulations had mass median aerodynamic diameter of 2.6 µm and fine particle fraction of 42%. The aerodynamic characteristic of the preparations was not influenced by the molecular weight of the copolymers. Therefore, it is suggested that both mPEG–DSPE are promising candidates as rifampicin carrier for pulmonary delivery.

实用2种不一样分子结构量的聚改性环氧树脂乙烷嵌段二硬脂酰磷脂酰酒精胺（mPEG2000-DSPE和mPEG5000-DSPE）缩聚物备制负债利福平的微米科粒。其他分析药制剂的粒级在162-395 nm依据内。包封率（EE）不会受共聚物团伙量的危害，当药剂与共聚物的比列为1:5时，才能得到了至高的EE（100%）。差示扫苗量热法（DSC）热图呈现，过载利福平的PEG-DSPE微米粉末的Tg高于较低值，说明利福平包埋在聚苯胺物栽培基质中。傅里叶调整红外光谱仪呈现，药剂与二种共聚物能够 之间无催化能够 用处。药溶液剂的离体中成药产生再次发生在3天内，依照特级产生能量学和Higuchi对外扩散建模。再水化冻干利福平mPEG-DSPE药溶液剂的吸雾效率中值气动式系统尺寸为2.6µm，细颗粒物考分为42%。药溶液剂的环境能量学形态不会受共聚物原子核量的影晌。因为，建意mPEG-DSPE全都是用作利福平双肺给药的载体的有行业发展前景的侯选者。相关推薦：C12-PEG-COOHC18-PEG-COOHC18-PEGn-COOHC18-PEGn-HydrazideC18-PEGn-MaleimideC18-PEGn-N3 (N3: Azide)C18-PEGn-NH2 (NH2: Amine)C18-PEGn-NHSC18-PEGn-OHC18-PEGn-OPSSC18-PEGn-SH (SH: Thiol)mPEG-Cholesterol (mPEG-CLS)上好的文章介绍由来各个学术期刊或参考文献，如果侵权行为请保持联系自己卸载！