资料：Lymphatic transport of orally administered probucol-loaded mPEG-DSPE micelles原作者：Limei Han,Qiushi Yang,Teng Shen,Jin Qing &Jianxin Wang期刊论文链接转换：//www.tandfonline.com/doi/full/10.3109/10717544.2015.1028600#abstractObjective: The formulation of polymer micelle was developed for probucol to improve its intestinal lymphatic transport.Materials and methods: Methoxy-polyethylenelglycol-distearyl phosphatidyl-ethanolamine (mPEG-DSPE) polymer was chosen to develop the micelles for probucol. The physicochemical properties were characterized. Caco-2 cell model, unconscious and conscious lymph duct cannulated rat models were established for in vitro and in vivo evaluation of lymphatic transport.Results: In vitro evaluation in the Caco-2 cell model showed that the micellar formulation could significantly increase the uptake and transport of probucol. The study in unconscious and conscious lymph duct cannulated rat models further verified the significant enhancement of lymphatic transport of probucol by mPEG-DSPE micelles.Discussion and conclusion: These results suggested that mPEG-DSPE micellar formulation could provide a useful alternative approach for improving the lymphatic transport of hydrophobic compounds.

目的性：发明普罗布考缩聚物胶束药物制剂，以缓和其肠管淋疤转运公司。原材料和方式 ：选甲氧基聚乙二醇二硬脂基磷脂酰工业乙醇胺（mPEG-DSPE）合成树脂物制作普罗布考胶束。对其理化检验规定性参与了定性分析。创建Caco-2组织仿真沙盘模型、不经发现和有发现淋疤管插管大鼠仿真沙盘模型，使用于离体和机体淋疤运送考核。毕竟：在Caco-2细胞膜类别中的身体之外测试取决于，胶束药制剂不错相关系数添加普罗布考的摄取量和运输公司。在不知情识和认识到淋疤管插管大鼠类别中的理论研究进一次证明了mPEG-DSPE胶束对普罗布考淋疤运输公司的相关系数加强。研讨和的结果：等的结果揭示，mPEG-DSPE胶束药品可不可以为改进疏水性聚氨酯化学物质的腮腺转运公司带来1种使用的混用步骤。涉及到最新推荐：Cy7-PEG-DPPEDSPE-PEG-Cy7DSPE-PEG-cRGDDPPE-PEG-cRGDDMPE-PEG-cRGDDOPE-PEG-cRGDDPPE-PEG-RGDDMPE-PEG-RGDDOPE-PEG-RGD4-Arm PEG-DSPE不低于小文章信息收入当下刊物或论文，假如有侵权案请电话联系你们刪除！