资料：BioMed Research International学术论文图片链接：//onlinelibrary.wiley.com/doi/full/10.1155/2014/129458文献综述：Postmodification of the liposome surface by amine-carboxyl conjugation (Figure 1(b)) was recently reported to overcome the rapid systemic clearance of D-phenylalanyl-L-prolyl-L-arginyl-chloromethyl ketone short peptide (PPACK), an antithrombin agent [30]. Palekar et al.  demonstrated that PPACK peptide is attached to the surface of preformed liposomes composed of EPC, DPPE, and DSPE-PEG2000-COOH (94 : 4 : 2 molar ratio) by applying standard amine-carboxyl coupling conditions for conjugating the N-terminus of the peptide to preformed carboxy-terminated DSPE-PEG-containing liposomes. The peptide was conjugated to the unilamellar liposomes and liposomes were purified by dialysis for four hours, which suggests high stability of the nanosystem. 

实施胺羧基偶联对脂质表皮面实施后体现，不错能克服抗凝血功能酶剂D-苯丙氨酰-L-脯氨酰基-L-精氨酰氯甲基酮短肽（PPACK）的高速混身消除。Palekar几人实施运用标准的胺羧基偶联情况将肽的N端偶联到再次构造的含羧基封鍴的DSPE-PEG的脂质体上，关系证明了PPACK肽依附在由EPC、DPPE和DSPE-PEG2000-COOH（94:4:2摩尔比）构造的再次构造的脂质体的表面上上。肽与单双层脂质体切合，脂质体实施透析41天纯化，这意味着奈米整体更具很高的维持性。相应安利：C18-PEGn-MaleimideC18-PEGn-N3 (N3: Azide)C18-PEGn-NH2 (NH2: Amine)C18-PEGn-NHSC18-PEGn-OHC18-PEGn-OPSSC18-PEGn-SH (SH: Thiol)mPEG-Cholesterol (mPEG-CLS)mPEG-CONH-C12mPEG-CONH-C16mPEG-CONH-C18以上的短文主要内容来历多种杂志期刊或论文，请谅解图片侵权请联系起来小编移除！