mPEG-DSPE/阿霉素胶束的制备及其淋巴结转移治疗效果研究
期刊论文：MPEG-DSPE混物物胶束主要用于腮腺腺结转出的经腮腺腺手术连接：//www.sciencedirect.com/science/article/abs/pii/S0378517315002902小说作品：雪莉，董 青，严志强，维岳 路，冯静怡，曹 协 阿，谢作旭，苏冰霞，刘 敏阿节选：本调查分离纯化了甲基聚乙二醇-二硬脂酰磷脂酰甲醇胺/阿霉素（MPEG-DSPE/DOX）胶束广泛用于*腮腺结移动。分离纯化的MPEG-DSPE/DOX胶束呈圆球形，粒度分布为20 ± 5nm。A375体内部核对DOX和MPEG-DSPE/DOX胶束的摄入率各用为51.2%和88.7%。RAW264.7体内部核对MPEG-DSPE/罗丹明B胶束的腐化率比独自施用罗丹明B低17.2倍。肉里注入后，MPEG-DSPE胶束经腮腺管吸附，在腘窝腮腺结中集中。 MPEG-DSPE/DOX胶束较独自DOX能显眼得到缓解注入位置肉里组织开展的软组织损伤。形成A375体内部核腮腺结移动裸鼠模特，肉里注入后，MPEG-DSPE/DOX胶束组腘窝腮腺结和髂窝腮腺结权重均显眼降到内分泌平台氯化钠组和DOX组。MPEG-DSPE/DOX胶束能更好破坏力腘窝腮腺结和髂窝腮腺结中的*体内部核。笔者认为说明，MPEG-DSPE胶束一种很有行业前景的*腮腺结移动的药物治疗递送平台。 AbstractLymph node metastasis is one of the major pathways for tumor formation and it is difficult to deliver chemotherapeutics at therapeutic concentrations to lymph node metastasis. This study prepared methyl poly(ethylene glycol)-distearoylphosphatidylethanolamine/doxorubicin (MPEG-DSPE/DOX) micelle for the treatment of lymph node metastasis. The MPEG-DSPE/DOX micelle prepared were of spherical morphology with a particle size of 20 ± 5 nm. The uptake rates of DOX and MPEG-DSPE/DOX micelle by A375 cells were 51.2% and 88.7%, respectively. The phagocytosis rate of MPEG-DSPE/Rhodamine B micelle by RAW264.7 cells was 17.2-fold lower than for Rhodamine B alone. After subcutaneous injection, MPEG-DSPE micelle underwent lymphatic absorption and accumulated in popliteal lymph nodes. MPEG-DSPE/DOX micelle significantly alleviated damage to the subcutaneous tissue of the injection sites compared with DOX alone. We established a model of nude mice bearing lymph node metastasis of A375 cells. After subcutaneous injection, the weights of both the popliteal and iliac lymph nodes of the MPEG-DSPE/DOX micelle group were significantly lower than in the saline and DOX groups. MPEG-DSPE/DOX micelle effectively killed the tumor cells in popliteal and iliac lymph nodes. In conclusion, MPEG-DSPE micelle is a promising drug delivery system for the treatment of lymph node metastasis.
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